I osteotomy. The third patient had bilateral mandibular ramus sagittal split osteotomies in combination with maxillary osteotomies. Two of the patients had preoperative electromyographic studies on the temporalis and masseter muscles. Postoperative and post-orthodontic stability was...

In retrosigmoid craniotomy, neurosurgeons usually depend on surface landmarks and their experience to evaluate the position of transverse-sigmoid sinus junction (TSSJ) and place an appropriate initial burr-hole, which is not accurate each time because of variability in different cran...

A total of 155 miRNAs were found with a signal above 500, among which, three miRNAs, hsa-miR-381, hsa-let-7g and bta-miR-376d, were differentially expressed between Con and OB fetuses, and confirmed by quantitative real-time PCR (QRT-PCR) analyses. Reduced expression of miRNA let-7g, an abundantly ex...

We performed a multicenter single-stage phase II trial of regorafenib in patients with advanced GIST after failure of at least imatinib and sunitinib. PATIENTS AND METHODSPatients received regorafenib orally, 160 mg daily, on days 1 to 21 of a 28-day cycle. Disease assessment was performed every two...

We report a facile and economic approach to fabricating catalytic active palladium (Pd) nanoparticle (NP)-immobilized electrospun polyethyleneimine (PEI)/polyvinyl alcohol (PVA) nanofibers for catalytic reduction of hexavalent chromium (Cr(VI)) to trivalent chromium (Cr(III)). In this study, PEI/PVA...

To investigate the effect of side-stream smoking on gut microflora composition, intestinal inflammation and expression of tight junction proteins. C57BL/6 mice were exposed to side-stream cigarette smoking for one hour daily over eight weeks. Cecal contents were colle...

The intermolecular interactions existing at three different sites between phenylacetylene and LiX (X = OH, NH(2) , F, Cl, Br, CN, NC) have been investigated by means of second-order Møller-Plesset perturbation theory (MP2) calculations and quantum theory of "atoms in molecules" (QTAIM) studies. At e...

We investigated the in vitro and in vivo effect of TMP in tumorigenesis and whether COX-2 is a molecular target of TMP. We showed that TMP exhibited a dose- and time-dependent inhibition on A549 cell proliferation by suppressing cell cycle progression. In vitro treatment of A549 cells with TMP resul...

We present a revised description of Parayunnanolepis and offer the first unambiguous evidence for the presence of pelvic girdles in antiarchs. As antiarchs are placed at the base of the gnathostome radiation in several recent studies, our finding shows that all jawed vertebrates (including antiarch...

These results imply that mPEG-PLGA-b-PLL NPs have a great potential to be used as an effective carriers for adriamycin or siRNA....

We identified 117 (2.4%) patients with mixed-phenotype acute leukemia fulfilling WHO 2008 criteria, classified: B-lymphoid+myeloid (n=64), T-lymphoid+myeloid (n=38), B+T-lymphoid (n=14), and trilineage (n=1). Of 92 patients karyotyped, 59 were abnormal, classified: complex (22/92), t(9;22)(q34;q11)...

We showed that LAT-deficient CTLs failed to upregulate FasL and produce interferon after engagement with target cells and had impaired granule-mediated killing. We further dissected the effect of the LAT deletion on each step of granule exocytosis. LAT-deficiency led to altered synapse formation, su...

We found a significant increased expression of ILT2 by lymphocytes in SLE patients. When the expression of this receptor was assessed in cell subsets, significantly higher ILT2 MRFI levels were detected in CD3+ cells, CD19+ cells, CD56+ cells (P < 0.05), but no change with ILT4 MRFI in CD14+ cells...

These results suggest that the enumeration should be completed as soon as possible within 24 h after sampling to analyze colonization and taxonomic relatedness features of periphytic ciliate communities, and that the species diversity and taxonomic distinctness measures can be used on a robust bioi...

We monitored the effect of Cd(2+) on calcium (Ca(2+) ) and potassium (K(+) ) transport in root hair cells of rice. Our results showed that K(+) and Ca(2+) contents in both roots and shoots were significantly reduced when treated with exogenous Cd(2+) . Further studies revealed that three cellular pr...

Phytochemical study of the leaves of the medicinal plant Isodon rubescens led to the isolation of three novel abietane diterpenoids, rubesanolides C-E (). These diterpenes contain a unique γ-lactone subgroup formed between C-8 and C-20. Their structures were determined from analysis...

We generated mice defective for both. Because complete ATR pathway inactivation causes embryonic lethality, we weakened the ATR mechanism to different degrees by impairing HUS1, a member of the 911 complex that is required for efficient ATR signaling. Notably, simultaneous ATM and HUS1 defects cause...

We show that MIF is essential for the development of neuropathic and inflammatory pain, and for stress-induced enhancement of neuropathic pain. Mif null mutant mice fail to develop pain-like behaviors in response to inflammatory stimuli or nerve injury. Pharmacological inhibition of MIF attenuates p...

We enumerated all the network topologies that can generate priming or tolerance. We discovered three major mechanisms for priming (pathway synergy, suppressor deactivation, activator induction) and one for tolerance (inhibitor persistence). These results not only explain existing experimental observ...

Lanthanide coordination polymers [LnL(DMF)(2)]·0.25H(2)O [Ln = La (1), Ce (2), Pr (3), Nd (4), Sm (5), Eu (6), Gd (7), Tb (8), Dy (9), Ho (10), Er (11), and Tm (12)], and [GdL(H(2)O)(3)] (7') (H(3)L = 5-(4-carboxy-2-nitrophenoxy)-isophthalic acid), have been synthesized under hydro- and solvothermal...