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  • Synergistic Signals for Natural Cytotoxicity Are Required to Overcome Inhibition by c-Cbl Ubiquitin Ligase.
    Natural killer (NK) cell cytotoxicity toward target cells depends on synergistic coactivation by NK cell receptors s...
    Immunity 32:175 (2010)
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  • Immobile BCRs: The Safety on the Signal Trigger.
    B cell receptor (BCR)-mediated tonic signals are important for B cell survival and development. In this issue of Imm...
    Immunity 32:143 (2010)
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  • For T Cell Receptors, Some Breakups Might Not Last Forever.
    Does the affinity or half-life of peptide-MHC-T cell receptor (TCR) interactions determine T cell activation? In thi...
    Immunity 32:141 (2010)
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  • The Ly49Q Receptor Plays a Crucial Role in Neutrophil Polarization and Migration by Regulating Raft Trafficking.
    We show that an inhibitory MHC I receptor, Ly49Q, was crucial for the swift polarization of and tissue infiltration by neutrophils....
    Immunity 32:200 (2010)
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  • In Vivo Requirement for Atg5 in Antigen Presentation by Dendritic Cells.
    I was intact in the absence of Atg5. Although induction of metabolic autophagy did not enhance MHC II presentation, autophagic machi...
    Immunity 32:227 (2010)
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  • A Deadly Migration.
    CD95 has long been viewed as a death receptor regulating apoptosis. In this issue of Immunity, Letellier et al. (201...
    Immunity 32:147 (2010)
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  • Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84.
    We found that whereas T cell:DC interactions were primarily integrin dependent, T cell:B cell interactions had both an early integri...
    Immunity 32:253 (2010)
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  • T Cell Receptor-Dependent Regulation of Lipid Rafts Controls Naive CD8+ T Cell Homeostasis
    T cell receptor (TCR) contact with self ligands keeps T cells alive and is shown here to cause naive CD8+, but not CD4+, T cells to b...
    Immunity 32:214 (2010)
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  • The Membrane Skeleton Controls Diffusion Dynamics and Signaling through the B Cell Receptor.
    We simultaneously visualize single BCR particles and components of the membrane skeleton. We show that an ezrin- and actin-defined n...
    Immunity 32:187 (2010)
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  • Quantitative Proteomics Reveals Subset-Specific Viral Recognition in Dendritic Cells.
    We used high-resolution mass spectrometry-based proteomics, combined with label-free quantitation algorithms, to determine the prote...
    Immunity 32:279 (2010)
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  • Foxp3+ T Cells Induce Perforin-Dependent Dendritic Cell Death in Tumor-Draining Lymph Nodes
    We showed the rejection of established ovalbumin (OVA)-expressing MCA101 tumors required both the adoptive transfer of OVA-specific...
    Immunity 32:266 (2010)
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  • CD95-Ligand on Peripheral Myeloid Cells Activates Syk Kinase to Trigger Their Recruitment to the Inflammatory Site.
    We showed that, in rodents and humans, injury to the spinal cord triggered surface expression of CD95 ligand (CD95L, FasL) on periph...
    Immunity 32: (2010)
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  • Dendritic Cell Subsets Digested: RNA Sensing Makes the Difference!
    In this issue of Immunity, Luber et al. (2010) report a comprehensive quantitative proteome of in vivo mouse spleen...
    Immunity 32:149 (2010)
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  • T Cells Use Rafts for Survival.
    T cell homeostasis must be tightly controlled. In this issue of Immunity, Cho et al. (2010) describe results that be...
    Immunity 32:145 (2010)
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  • Dependence of T Cell Antigen Recognition on T Cell Receptor-Peptide MHC Confinement Time.
    We analyze which binding properties of the TCR-pMHC interaction are responsible for this variation in pMHC activation potency. We ha...
    Immunity : (2010)
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  • Integrating Genomic Signatures for Immunologic Discovery.
    We discuss how integration of well-defined expression signatures across experimental conditions together with functional analysis of...
    Immunity 32:152 (2010)
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