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  • Interferons Direct Th2 Cell Reprogramming to Generate a Stable GATA-3+T-bet+ Cell Subset with Combined Th2 and Th1 Cell Functions
    We show that infection with Th1 cell-promoting lymphocytic choriomeningitis virus (LCMV) reprogrammed otherwise stably committed GAT...
    Immunity 32:116 (2010)
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  • CD4+ T Cell Plasticity—Th2 Cells Join the Crowd
    In this issue of Immunity, Hegazy et al. (2010) report that in response to lymphocytic choriomeningitis virus (LCMV) infection, full...
    Immunity 32:11 (2010)
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  • Thymoproteasome Shapes Immunocompetent Repertoire of CD8+ T Cells
    We show that cTECs displayed thymoproteasome-specific peptide-MHC class I complexes essential for the positive selection of major an...
    Immunity 32:29 (2010)
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  • Prolonged Interleukin-2Rα Expression on Virus-Specific CD8+ T Cells Favors Terminal-Effector Differentiation In Vivo
    We demonstrate that during an acute viral infection, CD25 expression is quite dynamic—after initial upregulation, a subset of viru...
    Immunity 32:91 (2010)
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  • CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients
    We demonstrate that human CD19+CD24hiCD38hi B cells possessed regulatory capacity. After CD40 stimulation, CD19+CD24hiCD38hi B cells...
    Immunity 32:129 (2010)
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  • The mTOR Kinase Determines Effector versus Memory CD8+ T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin
    We demonstrate that interleukin-12 (IL-12) enhanced and sustained antigen and costimulatory molecule (B7.1)-induced mTOR kinase acti...
    Immunity 32:67 (2010)
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  • Response: Characteristics of IL-17-Producing γδ T Cells
    No abstract is available for this article.Article Outline Main TextAcknowledgementsReferences
    Immunity 32:3 (2010)
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  • An Activation Marker Finds a Function
    In this issue of Immunity, Baaten et al. (2010) describe a previously unknown role for CD44 in counteracting Fas-mediated apoptosis...
    Immunity 32:9 (2010)
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  • Characteristics of IL-17-Producing γδ T Cells
    No abstract is available for this article.Article Outline Main Text Supplemental InformationReferences
    Immunity 32: (2010)
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  • Why CD8+ T Cells Need Diversity When Growing Up
    A thymus-specific subunit of the proteasome, β5t, was previously described and shown to be essential for positive selection of CD8+...
    Immunity 32:5 (2010)
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  • Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells
    We demonstrate a complex interplay between IL-2 and inflammatory signals during CTL differentiation. IL-2 stimulation induced the tr...
    Immunity 32:79 (2010)
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  • The Receptor SIGIRR Suppresses Th17 Cell Proliferation via Inhibition of the Interleukin-1 Receptor Pathway and mTOR Kinase Activation
    We showed here that SIGIRR, a negative regulator of IL-1 receptor and Toll-like receptor signaling, was induced during Th17 cell lin...
    Immunity 32:54 (2010)
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  • Interleukin-2 Tickles T Cell Memory
    The differentiation of peripheral T lymphocytes depends on interactions between intrinsic and extrinsic factors. In this issue of Imm...
    Immunity 32:7 (2010)
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  • Response: Characteristics of IL-17-Producing γδ T Cells
    No abstract is available for this article.Article Outline Main TextReferences
    Immunity 32: (2010)
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  • Distinct Melanization Pathways in the Mosquito Aedes aegypti
    We found that in the mosquito Aedes aegypti, there are two distinct melanization activation pathways carried out by different module...
    Immunity 32:41 (2010)
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  • CD44 Regulates Survival and Memory Development in Th1 Cells
    We report that CD44 was essential for the generation of memory T helper 1 (Th1) cells by promoting effector cell survival. This depe...
    Immunity 32:104 (2010)
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  • Notch Signaling in the Immune System
    We discuss Notch signaling in hematopoiesis, lymphocyte development, and function as well as in T cell acute lymphoblastic leukemia...
    Immunity 32:14 (2010)
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