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  • Signalling: Sensing a change | PDF (199 KB)
    According to Weber's law, our perception of sensations, such as light or sound, is based not on the absolute level of the stimulus bu...
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  • Correspondence: Empirical tests for compositional epistasis
    In her Review article (Detecting gene–gene interactions that underlie human diseases. Nature Rev.
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  • Genome architecture: Reliable repositioning in cancer | PDF (246 KB)
    One of the biggest challenges in cancer is proper diagnosis in the smallest possible amounts of tissue, such as that from a core need...
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  • Genomics: Building a giant in tiny steps | PDF (290 KB)
    A milestone in genome sequencing has been achieved with the publication of a draft sequence of the giant panda genome: the first larg...
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  • Personalized genomic information: preparing for the future of genetic medicine.
    We are rapidly approaching an era in which access to personalized genomic information is likely to be widespread. Here, four experts...
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  • The evolution of gene duplications: classifying and distinguishing between models.
    We present a comprehensive classification of the models that are relevant to all stages of the evolution of gene duplications. Each...
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  • Development: Male versus female | PDF (196 KB)
    In mammalian embryos the gonad can develop into either an ovary or a testis. The absence of the testis-determination gene, Sry, leads...
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  • Regulatory elements | Synthetic biology | Gene expression | Human evolution | PDF (150 KB)
    Regulatory elements Human genetic variation recognizes functional elements in non-coding sequence Lomelin, D., Jorgenson, E.|[nbsp]|...
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  • Cancer genomics: Genomic archeology | PDF (191 KB)
    Tumour cells accumulate somatic mutations over time, some of which are causal and some of which simply come along for the ride. Recen...
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  • Complex disease: Adding epigenetics to the mix | PDF (187 KB)
    Three recent papers highlight the importance of considering epigenetics in the study of both heritable and non-heritable influences o...
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  • How culture shaped the human genome: bringing genetics and the human sciences together.
    We collate these data, highlighting the considerable potential for cross-disciplinary exchange to provide novel insights into how cu...
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  • Genetics of mammalian meiosis: regulation, dynamics and impact on fertility.
    Meiosis is an essential stage in gamete formation in all sexually reproducing organisms. Studies of mutations in model organisms and...
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  • Complex disease: A mutational history of Alzheimer's | PDF (377 KB)
    A common polymorphism that accelerates the onset of the most common form of Alzheimer's disease (AD) by an average of 7 years has bee...
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  • Recombination: The gene that hits the hot spot | PDF (189 KB)
    Sites of meiotic recombination are highly localized on eukaryotic genomes, but the reason for this remains puzzling. Three papers now...
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  • Future directions in association studies for complex disease
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  • Epigenetics | Evolution | Plant genetics | Disease models | PDF (154 KB)
    Epigenetics Essential role of the histone methyltransferase G9a in cocaine-induced plasticity Maze, I. et al. Science 327, 213–216...
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  • Methodological challenges of genome-wide association analysis in Africa.
    We review the methodological challenges and consider how GWA studies in Africa will be transformed by new approaches in statistical...
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  • Deconstructing repression: evolving models of co-repressor action.
    We consider specific strategies that underlie repression events - for example, those mediated by the nuclear receptor co-repressor (...
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