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  • In this issue
    In humans and other animals, invading pathogens are recognized by the innate immune system. Innate immune cells express pattern recog...
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  • Infectious disease: Filarial factors promote lymphatic growth
    Lymphatic filariasis, a disease caused by the nematodes Brugia malayi and Wuchereria bancrofti, leads to elephantiasis, which is the...
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  • Immune evasion: CRISPRs hit the RNA target
    The system that protects bacterial and archaeal genomes from invading mobile genetic elements can target RNA as well as DNA, accordin...
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  • Bacterial pathogenicity: A closer look at intracellular EPEC
    A rare subset of enteropathogenic Escherichia coli (EPEC) isolates that can actively invade non-phagocytic host cells by inducing the...
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  • On the rocks: the microbiology of Antarctic Dry Valley soils.
    We review our understanding of these extreme Antarctic terrestrial microbial communities, with particular emphasis on the factors th...
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  • Breaking the wall: targeting of the endothelium by pathogenic bacteria.
    The endothelium lining blood and lymphatic vessels is a key barrier separating body fluids from host tissues and is...
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  • In the news
    The past month provided mixed fortunes for the HIV research community, with news that the largest international trial to date of an H...
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  • A sequence of changes
    2010 marks the fifteenth anniversary of the availability of the first complete bacterial genome sequence, that of Haemophilus influen...
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  • The pyramid of knowledge.
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  • Viral infection: Captured on (bio)film
    Transmission of human T lymphotrophic virus 1 (HTLV-1) occurs at transient points of cell-to-cell contact between T cells. At these p...
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  • Viral infection: Entry through tunnel vision
    Entry of simian virus 40 (SV40) particles into a host cell depends on the interaction between the major capsid protein (VP1) and a gl...
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  • Model or meal? Farm animal populations as models for infectious diseases of humans.
    In recent decades, theory addressing the processes that underlie the dynamics of infectious diseases has progressed...
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  • Immune evasion: Manipulating inflammation
    Similarly to many bacterial pathogens, Bordetella bronchiseptica, which has been used for the study of Bordetella pertussis pathogene...
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  • Microbial threat lists: obstacles in the quest for biosecurity?
    We discuss our view that such lists may have the paradoxical effect of increasing the societal vulnerability to biological attack an...
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  • Bacterial manipulation of innate immunity to promote infection.
    The mammalian innate immune response provides a barrier against invading pathogens. Innate immune mechanisms are used by the host to...
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  • Shiga toxins--from cell biology to biomedical applications.
    We summarize the Shiga toxin family members and their structures, receptors, trafficking pathways and cellular targets. We discuss h...
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  • In Brief
    Structure of the outer membrane complex of a type IV secretion system Chandran, V.et al. Nature 462, 1011–1015 (2009)Writing in Nat...
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