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  • Project set to map marks on genome
    At one time, sequencing the whole human genome seemed almost impossible. But even as it was being completed, biologists were realizin...
    Nature 463:596 (2010)
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  • IPCC flooded by criticism
    We have to do is to ensure full and complete compliance with the procedures while preparing IPCC's assessment reports." “I have no...
    Nature 463:596 (2010)
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  • Applied physics: Nanothermal trumpets
    The thermal process known as Joule heating, which often plagues electronic devices, has been turned to good use: making devices that...
    Nature 463:619 (2010)
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  • Women: why just one to represent half the workforce?
    In your prognostications about the future of science (Nature463, 26–32; 2010), you might have featured only women as authors, given...
    Nature 463:608 (2010)
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  • An aspartyl protease directs malaria effector proteins to the host cell
    We show that the protein responsible for cleavage of this motif is plasmepsin V (PMV), an aspartic acid protease located in the endo...
    Nature 463:627 (2010)
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  • Women: diversity among leaders is there if you look
    A disappointing myopia seems to have afflicted your '2020 visions' (Nature 463, 26–32; 2010), with just one female among the 20 con...
    Nature 463:608 (2010)
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  • Atmospheric physics: Bolt from the blue
    Nature 463:591 (2010)
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  • Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers
    We show by solid-state NMR spectroscopy that two amantadine-binding sites exist in M2 in phospholipid bilayers. The high-affinity si...
    Nature 463:689 (2010)
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  • Better all the time
    Scientists and policy-makers often insist that 'more research' is needed to solve a wide range of social challenges. But what is the...
    Nature 463:607 (2010)
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  • Time for the epigenome
    The complexity of genetic regulation is one of the great wonders of nature, but it represents a daunting challenge to unravel. The In...
    Nature 463:587 (2010)
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  • Chemistry: Breaking the billion-hertz barrier
    The 12-tonne, 4.5-metre-tall machine does little to betray the fact that it is working. There are currently no comments.
    Nature 463:605 (2010)
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  • Networking: Four ways to reinvent the Internet
    The Internet is feeling the strain. Developed in the 1970s and 1980s for a community of a few thousand researchers, most of whom knew...
    Nature 463:602 (2010)
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  • Multiple native states reveal persistent ruggedness of an RNA folding landscape
    We demonstrate, using single-molecule experiments, that an RNA enzyme folds into multiple distinct native states that interconvert o...
    Nature 463:681 (2010)
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  • Organic chemistry: Methylene magic
    Nature 463:590 (2010)
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  • A new highly penetrant form of obesity due to deletions on chromosome 16p11.2
    We report a highly penetrant form of obesity, initially observed in 31 subjects who were heterozygous for deletions of at least 593...
    Nature 463:671 (2010)
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  • The photosynthetic apparatus of cryptophyte algae is odd — its pigments are farther apart than is expected for efficient functionin...
    Nature 463:614 (2010)
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  • Physics: Plasma pinch
    Nature 463:590 (2010)
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  • Biochemistry: Chemical gene switch
    Nature 463:591 (2010)
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  • TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
    We show that Foxo3a has an essential role in the maintenance of CML LICs. We find that cells with nuclear localization of Foxo3a and...
    Nature 463:676 (2010)
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  • Biomaterials: Dew catchers
    Why did Incy Wincy Spider climb up the water spout? If he was after a drink, a report by Yongmei Zheng et al.Y. Zheng et al. Nature 4...
    Nature 463:618 (2010)
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  • Mars rover Spirit (2003–10)
    Spirit was born in 2003 to mission manager Mark Adler and Steven Squyres, a planetary scientist at Cornell University in Ithaca, New...
    Nature 463:600 (2010)
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  • 50 & 100 years ago
    Although the problem of alcohol and road safety has been much in the public eye, there has hitherto been little precise evidence as t...
    Nature 463:617 (2010)
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  • Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte
    We report that plasmepsin V, an ER aspartic protease with distant homology to the mammalian processing enzyme BACE, recognizes the P...
    Nature 463:632 (2010)
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  • Biodiversity law could stymie research
    Scientists who study the world's biodiversity are facing a dilemma: proposals to regulate access to the riches of ecological hotspots...
    Nature 463:598 (2010)
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  • America pushes to overhaul chemical safety law
    When it comes to commercial chemicals, the presumption of innocence may be coming to an end. The Toxic Substances Control Act (TSCA)...
    Nature 463:599 (2010)
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  • Could a boom in technologies trap Feynman's simulator?
    I believe that quantum simulation is slated for a breakthrough by 2020 (Nature 463, 26–32; 2010). In a groundbreaking lecture (Intl...
    Nature 463:608 (2010)
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  • News briefing: 4 February 2010
    The week in science. This article is best viewed as a PDF. Policy|Business|Events|Funding|Research|People|The week ahead|Number crun...
    Nature 463:592 (2010)
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  • Plug-and-play DNA
    A new synthetic-biology research lab in Emeryville, California, is recruiting its first seven scientists and engineers to design and...
    Nature :695 (2010)
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  • Obama budget backs basic science
    In the first federal budget proposal to fully reflect his priorities, US President Barack Obama has signalled strong support for scie...
    Nature 463:594 (2010)
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  • Back to books
    Researchers should be recognized for writing books to convey and develop science.
    Nature 463:588 (2010)
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  • Coherently wired light-harvesting in photosynthetic marine algae at ambient temperature
    We present two-dimensional photon echo spectroscopy10, 11, 12, 13 measurements on two evolutionarily related light-harvesting protei...
    Nature 463:644 (2010)
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  • A foot in the door
    I just wanted the chance to get my foot in the door and then I'd be fine once the interview was in my hands.” Moritz, who landed...
    Nature :696 (2010)
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  • Opposing microRNA families regulate self-renewal in mouse embryonic stem cells
    We show that the introduction of let-7 miRNAs—a family of miRNAs highly expressed in somatic cells—can suppress self-renewal in...
    Nature 463:621 (2010)
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  • Experimental evidence for a frustrated energy landscape in a three-helix-bundle protein family
    We show that landscape roughness (internal friction) is responsible for the slower folding and unfolding of R16 and R17. We use chim...
    Nature 463:685 (2010)
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  • Q&A: Peter Atkins on writing textbooks
    The success of Peter Atkins's classic textbook Physical Chemistry led him to trade research for full-time writing and teaching in the...
    Nature 463:612 (2010)
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  • Evidence for grid cells in a human memory network
    We show that the preferred firing directions of directionally modulated grid cells in rat entorhinal cortex are aligned with the gri...
    Nature 463:657 (2010)
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  • Directional water collection on wetted spider silk
    We show that the water-collecting ability of the capture silk of the cribellate spider Uloborus walckenaerius is the result of a uni...
    Nature 463:640 (2010)
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  • Political instability may be a contributor in the coming decade
    The next decade is likely to be a period of growing instability in the United States and western Europe, which could undermine the so...
    Nature 463:608 (2010)
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  • Boost for brain research
    A research and training consortium with a focus on combating neurodegenerative disorders is recruiting 23 PhD students for 3-year fel...
    Nature :695 (2010)
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  • Engineering: Sticky when wet
    Nature 463:590 (2010)
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  • Mammalian biodiversity on Madagascar controlled by ocean currents
    We show that currents could have transported the animals to the island and highlight evidence inconsistent with the land-bridge hypo...
    Nature 463:653 (2010)
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  • Expanded view of universities would be more realistic
    Tertiary education is poised for greater changes during the next decade than John Hennessey's vision implies (Nature 463, 26–32; 20...
    Nature 463:608 (2010)
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  • Stand and deliver
    Science has done well in the proposed US budget. Researchers need to justify the funding boost.
    Nature 463:587 (2010)
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  • Evolution: Flower power
    Nature 463:590 (2010)
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  • A ground-based near-infrared emission spectrum of the exoplanet HD 189733b
    We report ground-based observations of the dayside emission spectrum for HD 189733b between 2.0–2.4 μm and 3.1–4.1 μm, w...
    Nature 463:637 (2010)
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  • The atmospheric properties of distant worlds are becoming increasingly clear. The latest observations reveal fluorescent emission fro...
    Nature 463:617 (2010)
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  • Institute gets gift windfall
    A US$50-million gift to the Sanford-Burnham Medical Research Institute in La Jolla, California, will help to employ at least 30 resea...
    Nature :695 (2010)
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  • Embryonic stem cells can create copies of themselves, but can also mature into almost any type of cell in the body. Tiny gene regulat...
    Nature 463:616 (2010)
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  • Biogeography: Washed up in Madagascar
    How, when and from where did Madagascar's unique mammalian fauna originate? The idea that the ancestors of that fauna rafted from Afr...
    Nature 463:613 (2010)
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  • Jenna's clocks
    Get connected!
    Nature 463:700 (2010)
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  • Imaging: Virus vision
    Nature 463:591 (2010)
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  • Eric Barron
    We ought to be able to do a much better job with philanthropy. This is a challenge that was not present at NCAR. How do you propose...
    Nature :695 (2010)
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  • In Retrospect: Funes the Memorious
    When Rodrigo Quian Quiroga visited Jorge Luis Borges's private library, he found annotated books that bear witness to the writer's fa...
    Nature 463:611 (2010)
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  • Astrophysics: Starlight versus dark matter
    Nature 463:590 (2010)
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  • The woman behind HeLa
    Steve Silberman enjoys a moving account that probes racial and ethical issues in medicine through the story of the young mother whose...
    Nature 463:610 (2010)
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  • Evolutionary anthropology: Baby-like bonobos
    Nature 463:591 (2010)
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  • Hsp90 prevents phenotypic variation by suppressing the mutagenic activity of transposons
    We offer an additional, perhaps alternative, explanation for proposals of a concrete mechanism underlying canalization. We show that...
    Nature 463:662 (2010)
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  • Large, rare chromosomal deletions associated with severe early-onset obesity
    We investigated the contribution of copy number variation to obesity in 300 Caucasian patients with severe early-onset obesity, 143...
    Nature 463:666 (2010)
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  • Journal club
    Nature 463:591 (2010)
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  • Migrating tremors illuminate complex deformation beneath the seismogenic San Andreas fault
    I examine continuous seismic data from mid-2001 to 2008, identifying tremor and decomposing the signal into different families of ac...
    Nature 463:648 (2010)
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