Latest papers

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages.

3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds.

Nucleotide regulation of soluble guanylate cyclase substrate specificity.

First steps in the direction of synthetic, allosteric, direct inhibitors of thrombin and factor Xa.

A New Kind of Drug Target

Allosteric site variants of Haemophilus influenzae beta-carbonic anhydrase.

Pharmacochaperone-mediated rescue of calcium-sensing receptor loss-of-function mutants.

Helix Dipole Movement and Conformational Variability Contribute to Allosteric GDP Release in Gα i Subunits , ‡

Orthosteric and allosteric binding sites of P2X receptors.

Tetracyclic indole inhibitors of hepatitis C virus NS5B-polymerase.

Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead.

Allosteric inhibitors of Akt1 and Akt2: Discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity

Conformational changes in alpha 7 acetylcholine receptors underlying allosteric modulation by divalent cations.

Novel non-active site inhibitor of Cryptosporidium hominis TS-DHFR identified by a virtual screen

Intrasteric control of AMPK via the &ggr;₁ subunit AMP allosteric regulatory site

Q&A: Cooperativity.

The phylogeny of the aromatic amino acid hydroxylases revisited by characterizing phenylalanine hydroxylase from Dictyostelium discoideum.

Slow inactivation in Shaker K channels is delayed by intracellular tetraethylammonium.

Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both?

The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity.