Latest papers

Antagonism of LIN-17/Frizzled and LIN-18/Ryk in nematode vulva induction reveals evolutionary alterations in core developmental pathways.

Interrogation of the protein-protein interactions between human BRCA2 BRC repeats and RAD51 reveals atomistic determinants of affinity.

A mechanism for pituitary-resistance to thyroid hormone (PRTH) syndrome: a loss in cooperative coactivator contacts by thyroid hormone receptor (TR)beta2.

Ligand-dependent regulation of the activity of the orphan nuclear receptor, small heterodimer partner (SHP), in the repression of bile acid biosynthetic CYP7A1 and CYP8B1 genes.

Structural analysis of natural killer cell receptor protein 1 (NKR-P1) extracellular domains suggests a conserved long loop region involved in ligand specificity.

Immunostimulatory potential of silencing RNAs can be mediated by a non-uridine-rich toll-like receptor 7 motif.

Probing conformational states of modified helix 69 in 50S ribosomes.

A novel conserved targeting motif found in ABCA transporters mediates trafficking to early post-Golgi compartments.

Glucocorticoid receptor alpha isoform-selective regulation of antiapoptotic genes in osteosarcoma cells: a new mechanism for glucocorticoid resistance.

Modeling of the DNA-binding site of yeast Pms1 by mass spectrometry.

Active-site structure of a β-hydroxylase in antibiotic biosynthesis.

Large scale phosphoproteome profiles comprehensive features of mouse embryonic stem cells.

Amphipathic-Lipid-Packing-Sensor interactions with lipids assessed by atomistic molecular dynamics

Use of secondary structure element information in drug design: polypharmacology and conserved motifs in protein-ligand binding and protein-protein interfaces.

Microbial manipulation of receptor crosstalk in innate immunity.

Integrated mass spectrometry-based analysis of plasma glycoproteins and their glycan modifications.

Multiscale simulation reveals multiple pathways for H2 and O2 transport in a [NiFe]-hydrogenase.

Relating form and function of EF-hand calcium binding proteins.

CK1ε targets Cdc25A for ubiquitin-mediated proteolysis under normal conditions and in response to checkpoint activation.

Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells.