Latest papers

Following translation by single ribosomes one codon at a time.

Origin of amino acid homochirality: relationship with the RNA world and origin of tRNA aminoacylation.

Four-base codon-mediated saturation mutagenesis in a cell-free translation system.

A structural understanding of the dynamic ribosome machine.

Pentamidine binds to tRNA through non-specific hydrophobic interactions and inhibits aminoacylation and translation.

Unnatural translation initiation.

An operational RNA code for faithful assignment of AUG triplets to methionine.

Reprogramming the translation initiation for the synthesis of physiologically stable cyclic peptides.

A Flexible Peptide Tether Controls Accessibility of a Unique C-terminal RNA-binding Domain in Leucyl-tRNA Synthetases

Site-specific incorporation of keto amino acids into functional G protein-coupled receptors using unnatural amino acid mutagenesis.

Enzymatic tRNA acylation by acid and alpha-hydroxy acid analogues of amino acids.

Evidence from glycine transfer RNA of a frozen accident at the dawn of the genetic code.

1,3,5-Tri- and 1,3,4,5-tetra-substituted 1,4-diazepin-2-one solid-phase synthesis.

Misincorporation of amino acid analogues into proteins by biosynthesis.

Solid-phase combinatorial synthesis of a lysyl-tRNA synthetase (LysRS) inhibitory library.

Human tryptophanyl-tRNA synthetase binds with heme to enhance its aminoacylation activity.

Improved amber and opal suppressor tRNAs for incorporation of unnatural amino acids in vivo. Part 1: minimizing misacylation.

A universal plate format for increased throughput of assays that monitor multiple aminoacyl transfer RNA synthetase activities.

Efficiency of a self-aminoacylating ribozyme: effect of the length and base-composition of its 3' extension.

Symmetries by base substitutions in the genetic code predict 2(') or 3(') aminoacylation of tRNAs.