Latest papers

[Efficient treatment of chronic backache].

PDE4 inhibitors: a review of current developments (2005 - 2009).

Discovery of 1-[4-(3-Chlorophenylamino)-1-methyl-1 H -pyrrolo[3,2- c ]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a Brain Penetrant 5-Azaindole CB 2 Agonist for the Treatment of Chronic Pain

Design, synthesis, and structure-activity relationships of aminopyridine N-oxides, a novel scaffold for the potent and selective inhibition of p38 mitogen activated protein kinase.

5-HT(1A) receptor antagonism reverses and prevents fluoxetine-induced sexual dysfunction in rats.

[Systematic review of the therapeutics for prion diseases]

Novel and highly sensitive fluorescent assay for leucine aminopeptidases.

N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275

Enhancement of cortical extracellular 5-HT by 5-HT1A and 5-HT2C receptor blockade restores the antidepressant-like effect of citalopram in non-responder mice.

Relevance of dorsal raphe nucleus firing in serotonin 5-HT(2C) receptor blockade-induced augmentation of SSRIs effects.

PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblasts.

Anomalous photophysics of H1 antihistamines in aqueous solution.

Spectroscopic study of 2-(2-pyridyliminomethyl)phenol as a novel fluorescent probe for superoxide anion radicals and superoxide dismutase activity.

Effects of sustained serotonin reuptake inhibition on the firing of dopamine neurons in the rat ventral tegmental area.

Cardioprotection Induced by Adenosine A1 Receptor Agonists in a Cardiac Cell Ischemia Model Involves Cooperative Activation of Adenosine A2A and A2B Receptors by Endogenous Adenosine

Cardioprotection Induced by Adenosine A1 Receptor Agonists in a Cardiac Cell Ischemia Model Involves Cooperative Activation of Adenosine A2A and A2B Receptors by Endogenous Adenosine

Nonradiative decay of the lowest excited singlet state of 2-aminopyridine is considerably faster than the radiative decay.

Effect of repeated dose of erythromycin on the pharmacokinetics of roflumilast and roflumilast N-oxide.

AZD2184: a radioligand for sensitive detection of β-amyloid deposits

Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping.