Latest papers

Early effects of aluminum chloride on beta-secretase mRNA expression in a neuronal model of beta-amyloid toxicity.

Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10).

A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity.

Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014.

[Progress in the development of anti-amyloid drugs for treatment of Alzheimer's disease.].

Human ROBO1 is cleaved by metalloproteinases and gamma-secretase and migrates to the nucleus in cancer cells.

Novel gamma-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1.

Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.

Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity.

Xestosaprols from the Indonesian marine sponge Xestospongia sp.

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.

Design and synthesis of 1,4-dihydropyridine derivatives as BACE-1 inhibitors.

Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment.

Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leads.

Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound.

Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization.

Peroxisome proliferator-activated receptor gamma agonists as neuroprotective agents.

The sortilin-related receptor SORL1 and the amyloid cascade: a possible explanation for the concurrent elevation of CSF soluble APPalpha and APPbeta in Alzheimer's disease.

Secretory phospholipase A2 type III enhances alpha-secretase-dependent amyloid precursor protein processing through alterations in membrane fluidity.

Inhibition of gamma-secretase by the CK1 inhibitor IC261 does not depend on CK1delta.