Latest papers

Molecular Medicine - CHI's 17th International Tri-Conference: Mastering Medicinal Chemistry - CHI's Seventh Annual Conference.

7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin: More potent analogs of platensimycin

[Inhibitors of the Hedgehog signalling pathway: hope for the treatment of basal cell carcinoma].

Antagonistic interaction between bicalutamide (Casodex) and radiation in androgen-positive prostate cancer LNCaP cells.

A single amino acid substitution in the SdhB protein of succinate dehydrogenase determines resistance to amicarthiazol in Xanthomonas oryzae pv. oryzae.

Recent advances on platensimycin: a potential antimicrobial agent.

PPARgamma agonist curcumin reduces the amyloid-beta-stimulated inflammatory responses in primary astrocytes.

The novel function of nesfatin-1: Anti-hyperglycemia

GDC-0449--targeting the hedgehog signaling pathway.

The in vitro antibiofilm activity of selected culinary herbs and medicinal plants against Listeria monocytogenes.

Disseminated intravascular coagulation secondary to metastatic prostate cancer: case report and review of the literature.

Treatment of familial male-limited precocious puberty (testotoxicosis) with anastrozole and bicalutamide in a boy with a novel mutation in the luteinizing hormone receptor.

Isolation, structure and biological activities of platensimycin B4 from Streptomyces platensis.

Activation of peroxisome proliferator-activated receptor-gamma induces apoptosis on acute promyelocytic leukemia cells via downregulation of XIAP.

Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro- N -(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor

Antidepressant-like effects of rosiglitazone, a PPARγ agonist, in the rat forced swim and mouse tail suspension tests

Dutasteride and bicalutamide in patients with hormone-refractory prostate cancer: the Therapy Assessed by Rising PSA (TARP) study rationale and design.

The resurgence of thyromimetics as lipid-modifying agents.

Crystallization of mitochondrial rhodoquinol-fumarate reductase from the parasitic nematode Ascaris suum with the specific inhibitor flutolanil.

Palladium- and copper-catalyzed arylation of carbon-hydrogen bonds.