Latest papers

Cutting edge: a cis-acting DNA element targets AID-mediated sequence diversification to the chicken Ig light chain gene locus.

The immunoglobulin constant region contributes to affinity and specificity.

Antibody diversification by somatic mutation: from Burnet onwards.

The enunciation and impact of Macfarlane Burnet's clonal selection theory of acquired immunity.

Selection of anti-cancer antibodies from combinatorial libraries by whole-cell panning and stringent subtraction with human blood cells.

Quantitative and qualitative approaches to GOD: the first 10 years of the clonal selection theory.

G.O.D.'s Holy Grail: discovery of the RAG proteins.

Immunoglobulin gene conversion: synthesizing antibody diversification and DNA repair.

Reflections on the clonal-selection theory.

From XenoMouse technology to panitumumab, the first fully human antibody product from transgenic mice.

Kinetic, affinity, and diversity limits of human polyclonal antibody responses against tetanus toxoid.

Mutant tumor necrosis factor receptor associated with tumor necrosis factor receptor-associated periodic syndrome is altered antigenically and is retained within patients' leukocytes.

Identifying highly mutated IGHD genes in the junctions of rearranged human immunoglobulin heavy chain genes.

Early, microbially driven follicular reactions in the neonatal piglet do not contribute to expansion of the immunoglobulin heavy chain V-D-J repertoire.

Dominance and diversity in the primary human CD4 T cell response to replication-competent vaccinia virus.

Antibody repertoire development in fetal and neonatal piglets: XIX. Undiversified B cells with hydrophobic HCDR3s preferentially proliferate in the porcine reproductive and respiratory syndrome.

Design of synthetic antibody libraries.

VH replacement in mice and humans.

Heterogeneous antibody repertoire of marginal zone B cells specific for virus-like particles.

Igkappa allelic inclusion is a consequence of receptor editing.