Latest papers

Conjugation of a novel Apaf-1 inhibitor to peptide-based cell-membrane transporters: effective methods to improve inhibition of mitochondria-mediated apoptosis.

Essential postmitochondrial function of p53 uncovered in DNA damage-induced apoptosis in neurons.

The apoptosome: signalling platform of cell death.

Apoptosome dependent caspase-3 activation pathway is non-redundant and necessary for apoptosis in sympathetic neurons.

Identification of an inhibitor of caspase activation from heart extracts; ATP blocks apoptosome formation.

Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1.

Regulation of caspase-9 activity by differential binding to the apoptosome complex.

Silvestrol, a potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway without activation of executioner caspase-3 or -7.

Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma.

ARK, the Apaf-1 related killer in Drosophila, requires diverse domains for its apoptotic activity.

Apoptosome: a platform for the activation of initiator caspases.

Caspase-10 involvement in cytotoxic drug-induced apoptosis of tumor cells.

Mechanical aspects of apoptosome assembly.

The marine product cephalostatin 1 activates an endoplasmic reticulum stress-specific and apoptosome-independent apoptotic signaling pathway.

A mathematical model for apoptosome assembly: the optimal cytochrome c/Apaf-1 ratio.

Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis.

Ornithine decarboxylase prevents methotrexate-induced apoptosis by reducing intracellular reactive oxygen species production.