Latest papers

A clinical drug library screen identifies astemizole as an antimalarial agent.

An extension of the Early Treatment Diabetic Retinopathy Study (ETDRS) system for grading of diabetic macular edema in the Astemizole Retinopathy Trial.

Development, validation and utility of an in vitro technique for assessment of potential clinical drug-drug interactions involving P-glycoprotein.

A lingering mistake.

Molecular cloning and kinetic characterization of an aldehyde dehydrogenase gene in Klebsiella pneumoniae.

Identification and functional characterization of novel CYP2J2 variants: G312R variant causes loss of enzyme catalytic activity.

Effect of histamine receptor antagonists on aminophylline-induced seizures and lethality in mice.

Estimation of potency of HERG channel blockers: impact of voltage protocol and temperature.

Generalized lichen nitidus.

[Efficacy and safety of astemizole in the treatment of allergic rhinitis and urticaria: a systematic review with meta-analysis].

Mechanism of block of hEag1 K+ channels by imipramine and astemizole.

Validation of a [3H]astemizole binding assay in HEK293 cells expressing HERG K+ channels.

Interaction of astemizole, an H1 receptor antagonist, with conventional antiepileptic drugs in mice.

In vitro inhibition of human small intestinal and liver microsomal astemizole O-demethylation: different contribution of CYP2J2 in the small intestine and liver.

Antihistamines.

Histamine inhibits KCNQ2/KCNQ3 channel current via recombinant histamine H(1) receptors.

Development of telemetry system in the common marmoset--cardiovascular effects of astemizole and nicardipine.

Cardiotoxicity of new antihistamines and cisapride.

The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (HERG) mutations.

Assessment of the relationship between hyperalgesia and peripheral inflammation in magnesium-deficient rats.