Latest papers

Crystallization and preliminary X-ray crystallographic analysis of the hexameric human p97/VCP ND1 fragment in complex with the UBX domain of human FAF1.

Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling.

Inhibition of activated pericentromeric SINE/Alu repeat transcription in senescent human adult stem cells reinstates self-renewal.

Is there a "G spot" in sister chromatid cohesion resolution?

A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation.

Quantitative proteomics reveals the basis for the biochemical specificity of the cell-cycle machinery.

Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes.

Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase.

Altered nephrin and podoplanin distribution is associated with disturbed polarity protein PARD-3 and PARD-6 expressions in podocytes from preeclampsia.

Tumor suppressor gene ZAC/PLAGL1: altered expression and loss of the nonimprinted allele in pheochromocytomas.

Perinuclear Cohibin Complexes Maintain Replicative Life Span via Roles at Distinct Silent Chromatin Domains

Multiple regulatory mechanisms to inhibit untimely initiation of DNA replication are important for stable genome maintenance.

Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis.

ATMIN is required for maintenance of genomic stability and suppression of B cell lymphoma.

Ixr1 is required for the expression of the ribonucleotide reductase Rnr1 and maintenance of dNTP pools.

Ca(2+) signaling, genes and the cell cycle.

A breathtaking phenotype: unexpected roles of the DNA base damage response protein ASCIZ as a key regulator of early lung development.

Polo-like kinase 1 (Plk1) is expressed by cutaneous T-cell lymphomas (CTCLs), and its downregulation promotes cell cycle arrest and apoptosis.

E2F1 promotes the recruitment of DNA repair factors to sites of DNA double-strand breaks.

Give me a break, but not in mitosis: the mitotic DNA damage response marks DNA double-strand breaks with early signaling events.