Latest papers

Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects.

Phenotyping of cytochrome P450 2E1 in vitro and in vivo.

Expression of CYP2E1 in human nasopharynx and its metabolic effect in vitro.

Induction of CYP2B and CYP2E1 in precision-cut rat liver slices cultured in defined medium.

Simultaneous determination of paracetamol, chlorzoxazone, and related impurities 4-aminophenol, 4'-chloroacetanilide, and p-chlorophenol in pharmaceutical preparations by high-performance liquid chromatography.

Obesity-induced increase of CYP2E1 activity and its effect on disposition kinetics of chlorzoxazone in Zucker rats.

A study on the pharmacokinetics of chlorzoxazone in healthy Thai volunteers.

Simultaneous determination of chlorzoxazone and ketoprofen in binary mixtures and in ternary mixtures containing the chlorzoxazone degradation product by reversed-phase liquid chromatography.

Phenobarbital induces monkey brain CYP2E1 protein but not hepatic CYP2E1, in vitro or in vivo chlorzoxazone metabolism.

Effects of glucose supplementation on the pharmacokinetics of intravenous chlorzoxazone in rats with water deprivation for 72 h

Pharmacokinetics of chlorzoxazone in rats with diabetes: Induction of CYP2E1 on 6-hydroxychlorzoxazone formation.

Ageing is associated with increased expression but decreased activity of CYP2E1 in male Wistar rats.

Chlorzoxazone inhibits contraction of rat thoracic aorta.

Validation of incorporating flurbiprofen into the Pittsburgh cocktail.

In vivo and in vitro characterization of chlorzoxazone metabolism and hepatic CYP2E1 levels in African Green monkeys: induction by chronic nicotine treatment.

Hepatic disposition of the cytochrome P450 2E1 marker chlorzoxazone and its hydroxylated metabolite in isolated perfused rat livers.

Selective effects of nitric oxide on the disposition of chlorzoxazone and dextromethorphan in isolated perfused rat livers.

Clearance of unusual muscular uptake of F-18 FDG in the lower lumbar region on a repeat FDG-PET scan after oral chlorzoxazone intervention.

Therapeutic hypothermia-induced pharmacokinetic alterations on CYP2E1 chlorzoxazone-mediated metabolism in a cardiac arrest rat model.

CYP2A5-mediated activation and early ultrastructural changes in the olfactory mucosa: studies on 2,6-dichlorophenyl methylsulfone.