Latest papers

PKC zeta controls DNA topoisomerase-dependent human caspase-2 pre-mRNA splicing.

Medicinal chemistry and the molecular operating environment (MOE): application of QSAR and molecular docking to drug discovery.

DNA topoisomerases of Leishmania: the potential targets for anti-leishmanial therapy.

Contributions of the combined effects of topoisomerase mutations toward fluoroquinolone resistance in Escherichia coli.

[Mechanism of DNA damage and apoptosis induced by anticancer drugs through generation of reactive oxygen species].

The catalytically active tyrosine residues of both SPO11-1 and SPO11-2 are required for meiotic double-strand break induction in Arabidopsis.

Commentary: Oncologic drugs in patients with organ dysfunction: a summary.

Molecular and structural transactions at human DNA replication origins.

Design, docking, and synthesis of novel indeno[1,2-c]isoquinolines for the development of antitumor agents as topoisomerase I inhibitors.

A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.

RecQ helicases and topoisomerases: implications for genome stability in humans.

Unstabilized DNA breaks in lymphocytes of patients with different subsets of systemic sclerosis.

Design, synthesis and biological evaluation of new oligopyrrole carboxamides linked with tricyclic DNA-intercalators as potential DNA ligands or topoisomerase inhibitors

Tamoxifen inhibits topoisomerases, depletes mitochondrial DNA, and triggers steatosis in mouse liver.

IkappaBalpha independent induction of NF-kappaB and its inhibition by DHMEQ in Hodgkin/Reed-Sternberg cells.

Reverse gyrase: an insight into the role of DNA-topoisomerases.

Vaccinia topoisomerase mutants illuminate roles for Phe59, Gly73, Gln69 and Phe215.

Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.

The epidermal growth factor receptor and human topoisomerases represent potential cellular targets of oligomeric procyanidins.

Resistance-associated signatures in breast cancer.