Latest papers

Assessment of in vivo CYP2D6 activity: differential sensitivity of commonly used probes to urine pH.

The roles of amino acid residues at positions 43 and 45 in microsomal contents and enzymatic functions of rat CYP2D1 and CYP2D2.

In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto.

Relationship between haloperidol plasma concentration, debrisoquine metabolic ratio, CYP2D6 and CYP2C9 genotypes in psychiatric patients.

Pharmacokinetic and pharmacodynamic assessment of a five-probe metabolic cocktail for CYPs 1A2, 3A4, 2C9, 2D6 and 2E1.

[CYP 2D6 activity profile among patients with depression].

Altered distribution of the debrisoquine oxidative phenotypes in children with type 1 diabetes mellitus.

The hepatic and intestinal metabolic activities of P450 in rats with surgery- and drug-induced renal dysfunction.

Effect of ketoconazole on venlafaxine plasma concentrations in extensive and poor metabolisers of debrisoquine.

Disposition of debrisoquine and nortriptyline in Korean subjects in relation to CYP2D6 genotypes, and comparison with Caucasians.

Coordinated intrahepatic and extrahepatic regulation of cytochrome p4502D6 in healthy subjects and in patients after liver transplantation.

Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype.

Interaction of serum proteins with CYP isoforms in human liver microsomes: inhibitory effects of human and bovine albumin, alpha-globulins, alpha-1-acid glycoproteins and gamma-globulins on CYP2C19 and CYP2D6.

Effect of hepatic impairment on the pharmacokinetics of atomoxetine and its metabolites

QTc interval lengthening is related to CYP2D6 hydroxylation capacity and plasma concentration of thioridazine in patients.

Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate?

New allelic arrangement CYP2D6*36 x 2 found in a Japanese poor metabolizer of debrisoquine.

Effect of nortriptyline and paroxetine on CYP2D6 activity in depressed elderly patients.

Is cytochrome P450 CYP2D activity present in pig liver?

Catalytic specificity of CYP2D isoforms in rat and human.