Latest papers

Analysis of Protein Conformation and Dynamics by Hydrogen/Deuterium Exchange MS

Peptide conformer acidity analysis of protein flexibility monitored by hydrogen exchange.

The mechanism of the reaction catalyzed by uronate isomerase illustrates how an isomerase may have evolved from a hydrolase within the amidohydrolase superfamily.

Hydrogen/deuterium exchange mass spectrometry with top-down electron capture dissociation for characterizing structural transitions of a 17 kDa protein.

Mechanism of flavin reduction and oxidation in the redox-sensing quinone reductase Lot6p from Saccharomyces cerevisiae.

Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2.

Radical Triplets and Suicide Inhibition in Reactions of 4-Thia- d - and 4-Thia- l -lysine with Lysine 5,6-Aminomutase ‡

Local and Global Effects of a Cavity Filling Mutation in a Metastable Serpin

Effect of active-site mutation at Asn67 on the proton transfer mechanism of human carbonic anhydrase II.

Functional dynamics of the folded ankyrin repeats of I kappa B alpha revealed by nuclear magnetic resonance.

Mapping of the allosteric network in the regulation of alpha-isopropylmalate synthase from Mycobacterium tuberculosis by the feedback inhibitor L-leucine: solution-phase H/D exchange monitored by FT-ICR mass spectrometry.

Biophysical investigation of GpIbalpha binding to thrombin anion binding exosite II.

Proton transfer and H/D isotopic exchange of water molecules mediated by hydroxide ions on ice film surfaces.

Characterization of nucleic acid higher order structure by gas-phase H/D exchange in a quadrupole-FT-ICR mass spectrometer.

Dynamics in Thermotoga neapolitana adenylate kinase: 15N relaxation and hydrogen-deuterium exchange studies of a hyperthermophilic enzyme highly active at 30 degrees C.

Hydrogen/deuterium exchange mass spectrometry.

Epitope mapping by amide hydrogen/deuterium exchange coupled with immobilization of antibody, on-line proteolysis, liquid chromatography and mass spectrometry.

Structural differences between Abeta(1-40) intermediate oligomers and fibrils elucidated by proteolytic fragmentation and hydrogen/deuterium exchange.

The calcium-modulated structures of calmodulin and S100b proteins are useful to monitor hydrogen/deuterium exchange efficiency using matrix-assisted laser desorption ionization time-of-flight mass spectrometry.

Alternative I-D exchange reaction on pyrimidine and purine nuclei mediated by tributyltin hydride using THF-d8 as a deuterium source.