Latest papers

Sequence recognition in the minor groove of DNA by covalently linked formamido imidazole-pyrrole-imidazole polyamides: effect of H-pin linkage and linker length on selectivity and affinity.

CoMFA study of distamycin analogs binding to the minor-groove of DNA: a unified model for broad-spectrum activity.

Non-covalent ligand/DNA interactions: minor groove binding agents.

Design, synthesis and biological evaluation of new oligopyrrole carboxamides linked with tricyclic DNA-intercalators as potential DNA ligands or topoisomerase inhibitors

Distamycin A enhances the cytotoxicity of duocarmycin A and suppresses duocarmycin A-induced apoptosis in human lung carcinoma cells.

Carbocyclic analogues of lexitropsin--DNA affinity and endonuclease inhibition.

Liposomes and micellar dispersions for delivery of benzoheterocyclic derivatives of distamycin A.

Hybrid molecules between distamycin A and active moieties of antitumor agents.

Synthesis and biophysical evaluation of minor-groove binding C-terminus modified pyrrole and imidazole triamide analogs of distamycin.

Thermodynamic analysis of quadruplex DNA-drug interaction.

DNA minor groove pharmacophores describing sequence specific properties.

Binding of f-PIP, a pyrrole- and imidazole-containing triamide, to the inverted CCAAT box-2 of the topoisomerase IIalpha promoter and modulation of gene expression in cells.

The amino-terminus of mouse DNA methyltransferase 1 forms an independent domain and binds to DNA with the sequence involving PCNA binding motif.

Physical and structural basis for the strong interactions of the -ImPy- central pairing motif in the polyamide f-ImPyIm.

Synthesis of distamycin A polyamides targeting G-quadruplex DNA.

Configurational Entropy Change of Netropsin and Distamycin upon DNA Minor-Groove Binding

Novel amidine analogue of melphalan as a specific multifunctional inhibitor of growth and metabolism of human breast cancer cells.

The binding of DNA intercalating and non-intercalating compounds to A-form and protonated form of poly(rC).poly(rG): spectroscopic and viscometric study.

Preferential formation of (5S,6R)-thymine glycol for oligodeoxyribonucleotide synthesis and analysis of drug binding to thymine glycol-containing DNA.

Characterization of the binding of distamycin A to damaged DNA: a comparison with the DNA recognition of the human DDB protein.