Latest papers

Delta opioid receptor analgesia: recent contributions from pharmacology and molecular approaches.

Large-scale similarity search profiling of ChEMBL compound data sets.

A data mining method to facilitate SAR transfer.

From activity cliffs to activity ridges: informative data structures for SAR analysis.

Lessons learned from molecular scaffold analysis.

Effort launched to adapt HIV/AIDS drugs for children.

Tear me down: role of calpain in the development of cardiac ventricular hypertrophy.

A breath of fresh air.

Identification of novel 5-hydroxy-1H-indole-3-carboxylates with anti-HBV activities based on 3D QSAR studies.

Prediction of human oral plasma concentration-time profiles using preclinical data: comparative evaluation of prediction approaches in early pharmaceutical discovery.

Proteins with complex architecture as potential targets for drug design: a case study of Mycobacterium tuberculosis.

Anti-tubercular drug designing by structure based screening of combinatorial libraries.

Rimonabant redux and strategies to improve the future outlook of CB1 receptor neutral-antagonist/inverse-agonist therapies.

Vascular endothelial growth factor-targeted therapy for the treatment of renal cell carcinoma.

Post-self-assembly covalent chemistry of discrete multicomponent metallosupramolecular hexagonal prisms.

Design strategies for bivalent ligands targeting GPCRs.

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice.

3D-QSAR and docking studies on the HEPT derivatives of HIV-1 reverse transcriptase.

Design, synthesis and biological evaluation of new 2-benzoxazolinone derivatives as potential cholinesterase inhibitors for therapy of alzheimer's disease.

The role of monoclonal antibodies in the treatment of severe asthma.