Latest papers

Cofactor regeneration for sustainable enzymatic biosynthesis.

Calculation of equilibrium compositions of systems of enzyme-catalyzed reactions.

Influence of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on ubiquinone levels in rat skeletal muscle and heart: relationship to cytotoxicity and inhibitory activity for cholesterol synthesis in human skeletal muscle cells.

Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice.

Vitamins: not just for enzymes.

Free radical mechanisms in enzymology.

The effect of oxygen on biochemical networks and the evolution of complex life.

Dietary sesamin and docosahexaenoic and eicosapentaenoic acids synergistically increase the gene expression of enzymes involved in hepatic peroxisomal fatty acid oxidation in rats.

One-pot chemo-enzymatic synthesis of reporter-modified proteins.

SC-435, an ileal apical sodium-codependent bile acid transporter inhibitor alters mRNA levels and enzyme activities of selected genes involved in hepatic cholesterol and lipoprotein metabolism in guinea pigs.

Understanding nature's catalytic toolkit.

Vitamin B12: chemistry and biochemistry.

Experimental observation of thiamin diphosphate-bound intermediates on enzymes and mechanistic information derived from these observations

Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma.

Pathology of mitochondrial encephalomyopathies.

Using enzymes isolated from diverse sources to determine metal ion cofactors.

Defective remethylation of homocysteine is related to decreased synthesis of coenzymes B2 in thyroidectomized rats.

Promotion of oxygen atom transfer in Mo and W enzymes by bicyclic forms of the pterin cofactor.

metaSHARK: software for automated metabolic network prediction from DNA sequence and its application to the genomes of Plasmodium falciparum and Eimeria tenella.

DSD--an integrated, web-accessible database of Dehydrogenase Enzyme Stereospecificities.