Latest papers

Comparative homology modeling-inspired protein engineering for improvement of catalytic activity of Mugil cephalus epoxide hydrolase.

Tryptophan fluorescence quenching by enzyme inhibitors as a tool for enzyme active site structure investigation: epoxide hydrolase.

14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition.

A long-wavelength, fluorogenic probe for epoxide hydrolase: 7-(2-(oxiran-2-yl)ethoxy) resorufin.

Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography

Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo

Genetic variation of genes for xenobiotic-metabolizing enzymes and risk of bronchial asthma: the importance of gene-gene and gene-environment interactions for disease susceptibility.

Biotechnological production of enantiopure epoxides by enzymatic kinetic resolution.

Alteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolase.

Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia.

Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors

The Expression of Human Microsomal Epoxide Hydrolase Is Predominantly Driven by a Genetically Polymorphic Far Upstream Promoter

Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase.

Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus.

The role of epoxide hydrolase Y113H gene variant in pancreatic diseases.

Cloning and characterization of an epoxide hydrolase from Novosphingobium aromaticivorans

Epoxide hydrolases are not only a molecular sponge sucking up genotoxic epoxides: new roles in control of blood pressure, inflammation as well as nociception and cell proliferation.

Mammalian epoxide hydrolases in xenobiotic metabolism and signalling.

Salicylate–urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities

Genetic associations with hypoxemia and pulmonary arterial pressure in COPD.