Latest papers

Porphyrin Binding and Distortion and Substrate Specificity in the Ferrochelatase Reaction: The Role of Active Site Residues

The C-terminal extension of ferrochelatase is critical for enzyme activity and for functioning of the tetrapyrrole pathway in Synechocystis strain PCC 6803.

Identification of a ferrochelatase mutation in a Chinese family with erythropoietic protoporphyria.

Silencing of human ferrochelatase causes abundant protoporphyrin-IX accumulation in colon cancer.

A 10376 bp deletion of FECH gene responsible for erythropoietic protoporphyria

Heme synthase (ferrochelatase) catalyzes the removal of iron from heme and demetalation of metalloporphyrins.

Gene dosage analysis identifies large deletions of the FECH gene in 10% of families with erythropoietic protoporphyria.

Erythropoiesis and iron metabolism in dominant erythropoietic protoporphyria.

A novel mutation of the FECH gene in a Chinese family with erythropoietic protoporphyria

A π-Helix Switch Selective for Porphyrin Deprotonation and Product Release in Human Ferrochelatase

Late presentation of erythropoietic protoporphyria: case report and genetic analysis of family members.

Clinical, biochemical, and genetic study of 11 patients with erythropoietic protoporphyria including one with homozygous disease.

Sulfite reduction in mycobacteria.

HEMA RNAi silencing reveals a control mechanism of ALA biosynthesis on Mg chelatase and Fe chelatase.

Stimulation of fecal fat excretion and the disposal of protoporphyrin in a murine model for erythropoietic protoporphyria.

Altered orientation of active site residues in variants of human ferrochelatase. Evidence for a hydrogen bond network involved in catalysis.

Direct measurement of metal ion chelation in the active site of human ferrochelatase.

The CHLI1 subunit of Arabidopsis thaliana magnesium chelatase is a target protein of the chloroplast thioredoxin.

Novel human pathological mutations. Gene symbol: FECH. Disease: porphyria, erythropoietic.

Expression of genes involved in heme biosynthesis in the human retinoblastoma cell lines WERI-Rb-1 and Y79: implications for photodynamic therapy.