Latest papers

Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer.

Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models.

Expression of tumour-suppressing chemokine BRAK/CXCL14 reduces cell migration rate of HSC-3 tongue carcinoma cells and stimulates attachment to collagen and formation of elongated focal adhesions in vitro.

Leucine-rich glioma inactivated 3 induces neurite outgrowth through Akt and focal adhesion kinase.

[Musculoskeletal rehabilitation and bone. A novel approach to mechanotransduction using cell-adhesion-patterned cells]

The influence of surface energy on early adherent events of osteoblast on titanium substrates.

Growth and survival signalling in B16F10 melanoma cells in 3D culture.

Overexpression of macrophage inhibitory cytokine-1 induces metastasis of human prostate cancer cells through the FAK-RhoA signaling pathway.

Integrin cleavage regulates bidirectional signalling in vascular smooth muscle cells.

Fibronectin-integrin mediated signaling in human cervical cancer cells (SiHa).

Progesterone receptor enhances breast cancer cell motility and invasion via extranuclear activation of focal adhesion kinase.

Immunohistochemical study of heat shock protein 27 with respect to survival and regeneration of proximal tubular cells after uranyl acetate-induced acute tubular injury in rats.

Integrins and signal transduction.

Culture of K562 human myeloid leukemia cells in presence of fibronectin expresses and secretes MMP-9 in serum-free culture medium.

Dasatinib reduces FAK phosphorylation increasing the effects of RPI-1 inhibition in a RET/PTC1-expressing cell line.

All-trans retinoic acid (ATRA) downregulates MMP-9 by modulating its regulatory molecules.

Polyamine-dependent activation of Rac1 is stimulated by focal adhesion-mediated Tiam1 activation.

Focal adhesion kinase and p53 signal transduction pathways in cancer.

Toxic effects of iron oxide nanoparticles on human umbilical vein endothelial cells.

The chemopreventive retinoid 4HPR impairs prostate cancer cell migration and invasion by interfering with FAK/AKT/GSK3beta pathway and beta-catenin stability.