Latest papers

LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis.

A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis. LID - 10.1111/j.1742-4658.2011.08178.x [doi]

Pyruvate dehydrogenase phosphatase 1 (PDP1) null mutation produces a lethal infantile phenotype

Importance of space and competition in optimizing genetic control strategies.

Conditional embryonic lethality to improve the sterile insect technique in Ceratitis capitata (Diptera: Tephritidae).

Arabidopsis cytosolic Nbp35 homodimer can assemble both [2Fe–2S] and [4Fe–4S] clusters in two distinct domains

Expression analysis and essential role of the putative tyrosine phosphatase His-domain-containing protein tyrosine phosphatase (HD-PTP).

Evaluation of allele frequencies of inherited disease genes in subgroups of American Quarter Horses.

Constraint-based analysis of metabolic capacity of Salmonella typhimurium during host-pathogen interaction.

A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines.

A killer-rescue system for self-limiting gene drive of anti-pathogen constructs.

SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis.

The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure.

Chromosome instability and tumor lethality suppression in carcinogenesis.

Integrated genomic and pharmacological approaches to identify synthetic lethal genes as cancer therapeutic targets.

The petit rat (pet/pet), a new semilethal mutant dwarf rat with thymic and testicular anomalies.

A novel method to generate unmarked gene deletions in the intracellular pathogen Rhodococcus equi using 5-fluorocytosine conditional lethality.

C2cd3 is required for cilia formation and Hedgehog signaling in mouse.

Igf2r improves the survival and transmission ratio of Igf2 transgenic mice.

Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.