Latest papers

IL4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosis.

Progress and prospects: gene therapy for genetic diseases with helper-dependent adenoviral vectors.

Development of a suspension serum-free helper-dependent adenovirus production system and assessment of co-infection conditions.

Role of chromatin structure in integration of helper-dependent adenoviral vectors containing the beta-globin locus control region.

Absence of an intrathecal immune reaction to a helper-dependent adenoviral vector delivered into the cerebrospinal fluid of non-human primates.

SaPI mutations affecting replication and transfer and enabling autonomous replication in the absence of helper phage.

Hexamethylene bisacetamide leads to reduced helper virus-free HSV-1 amplicon expression titers via suppression of ICP0.

Characterizing clearance of helper adenovirus by a clinical rAAV1 manufacturing process

Transcomplementation and synergism in plants: implications for viral transgenes?

Methods for the production of helper-dependent adenoviral vectors.

Helper-dependent adenovirus-mediated gene transfer into the adult mouse cochlea.

Antigen-specific tolerance of human alpha1-antitrypsin induced by helper-dependent adenovirus.

Different modulation of cellular transcription by adenovirus 5, DeltaE1/E3 adenovirus and helper-dependent vectors.

Oncolytic virotherapy with an HSV amplicon vector expressing granulocyte-macrophage colony-stimulating factor using the replication-competent HSV type 1 mutant HF10 as a helper virus.

Differential amplification of adenovirus vectors by flanking the packaging signal with attB/attP-PhiC31 sequences: implications for helper-dependent adenovirus production.

Tobacco mosaic virus defective RNAs expressing C-terminal methyltransferase domain sequences are severely impaired in long-distance movement in Nicotiana benthamiana.

Transducing particles of Staphylococcus aureus pathogenicity island SaPI1 are comprised of helper phage-encoded proteins.

Packaged replicons of bovine viral diarrhea virus are capable of inducing a protective immune response.

Helper-dependent adenovirus for the gene therapy of proliferative retinopathies: stable gene transfer, regulated gene expression and therapeutic efficacy.

[A novel system for producing lentiviral vectors].