Latest papers

Increased expression of inducible nitric oxide synthase (iNOS) in N-nitrosobis(2-oxopropyl)amine-induced hamster pancreatic carcinogenesis and prevention of cancer development by ONO-1714, an iNOS inhibitor.

A synthesis of N-bridged 5,6-bicylic pyridines via a mild cyclodehydration using the burgess reagent and discovery of a novel carbamylsulfonylation reaction.

Discovery of novel small-molecule inhibitors of human epidermal growth factor receptor-2: combined ligand and target-based approach.

Methylpiperate derivatives from Piper longum and their inhibition of monoamine oxidase.

Identification of Plasmodium falciparum spermidine synthase active site binders through structure-based virtual screening.

Synthesis and proteomic activity evaluation of a new isotope-coded affinity tagging (ICAT) reagent.

Synthesis, anti-bacterial, anti-asthmatic and anti-diabetic activities of novel N-substituted-2-(4-phenylethynyl-phenyl)-1H-benzimidazoles and N-substituted 2[4-(4,4-dimethyl-thiochroman-6-yl-ethynyl)-phenyl)-1H-benzimidazoles.

Synthesis, structure elucidation and identification of antitumoural properties of novel fused 1,2,4-triazine aryl derivatives.

Induced daldinin A, B, C with a new skeleton from cultures of the ascomycete Daldinia concentrica.

Rationalizing the activities of diverse cholecystokinin 2 receptor antagonists using molecular field points.

N6-substituted C5'-modified adenosines as A1 adenosine receptor agonists.

A case of concomitant polymorphism and spontaneous resolution: the tetragonal phase of 5-hydroxymethyl-7,7,N-trimethyl-6-oxabicyclo[3.2.1]octane-1-carboxamide.

A hydrogen-bonded chain of rings in 5-amino-1-(4-methoxybenzoyl)-3-methylpyrazole and a three-dimensional hydrogen-bonded framework in 5-amino-3-methyl-1-(2-nitrobenzoyl)pyrazole.

Alpha-amination of nitrogen heterocycles: ring-fused aminals.

Disposition and metabolism of [14C]brasofensine in rats, monkeys, and humans.

Two new metabolites from the mangrove endophytic fungus no. 2106.

cis-Jasmone induces accumulation of defence compounds in wheat, Triticum aestivum.

Sterically and polarity-controlled reactions of tBuLi with P=CH-NR heterocycles: novel heterocyclic P- and P,O-ligands and preliminary tests in transition-metal catalysis.

Structural diversity of bicyclic amino acids.

Diversity-oriented synthesis towards conceptually new highly modular aminal-pyrrolidine organocatalysts.