Latest papers

The functional significance of microRNA-145 in prostate cancer.

Epigenetic regulation affects N-myc downstream-regulated gene 1 expression indirectly in pancreatic cancer cells.

Inhibition of histone deacetylase protects the retina from ischemic injury.

gp-91 mediates histone deacetylase inhibition-induced cardioprotection.

Notch- and vitamin D signaling in 1,25(OH)2D3-resistant glioblastoma multiforme (GBM) cell lines.

The role of host factors and bacterial virulence genes in the development of pyelonephritis caused by Escherichia coli in renal transplant recipients.

The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis, down-regulates the CXCR4 chemokine receptor and impairs migration of chronic lymphocytic leukemia cells.

A comparison of differentiation protocols for RGC-5 cells.

Human ROBO1 is cleaved by metalloproteinases and gamma-secretase and migrates to the nucleus in cancer cells.

Promoter hypomethylation contributes to the expression of MUC3A in cancer cells.

A phase I study of the safety and pharmacokinetics of the histone deacetylase inhibitor belinostat administered in combination with carboplatin and/or paclitaxel in patients with solid tumours.

Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function .

The HDAC inhibitor LBH589 (panobinostat) is an inhibitory modulator of aromatase gene expression.

Reciprocal epigenetic modification of histone H2B occurs in chromatin during apoptosis in vitro and in vivo.

Effects of hydroxamate metalloendoprotease inhibitors on botulinum neurotoxin A poisoned mouse neuromuscular junctions.

Effect of EGF-induced HDAC6 activation on corneal epithelial wound healing.

Synthesis and preliminary antibacterial evaluation of 2-butyl succinate-based hydroxamate derivatives containing isoxazole rings.

Function and regulatory mechanisms of the candidate tumor suppressor receptor protein tyrosine phosphatase gamma (PTPRG) in breast cancer cells.

HDAC4 inhibits the transcriptional activation of mda-7/IL-24 induced by Sp1.

A phase I study of oral panobinostat alone and in combination with docetaxel in patients with castration-resistant prostate cancer.