Latest papers

A general approach to the synthesis of 1-deoxy-L-iminosugars.

Fmoc-protected iminosugar modified asparagine derivatives as building blocks for glycomimetics-containing peptides.

Pharmacological enhancement of mutated alpha-glucosidase activity in fibroblasts from patients with Pompe disease.

Preliminary studies on the transformation of nitrosugars into branched chain iminosugars: synthesis of 1,4-dideoxy-4-C-hydroxymethyl-1,4-imino-pentanols.

Imino sugars are potent agonists of the human glucose sensor SGLT3.

Tandem Staudinger-azaWittig mediated ring expansion: rapid access to new isofagomine-tetrahydroxyazepane hybrids.

The dual face of endogenous alpha-aminoketones: pro-oxidizing metabolic weapons.

The structural basis of glycosidase inhibition by five-membered iminocyclitols: the clan a glycoside hydrolase endoglycoceramidase as a model system.

[Iminosugars: current and future therapeutic applications].

C-Alkyl 5-membered ring imino sugars as new potent cytotoxic glucosylceramide synthase inhibitors.

Inhibition of chitin synthase by a series of 7-deoxycasuarine stereoisomers designed as constrained analogues of the potent inhibitor 6-deoxyhomoDMDP.

Synthesis of new amino sugar derivatives from keto-sugars of D-xylose.

Access to piperidine imino-C-glycosides via stereoselective thiazole-based aminohomologation of pyranoses.

Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition.

Diastereoselective synthesis of novel iminosugar-containing UDP-Galf mimics: potential inhibitors of UDP-Gal mutase and UDP-Galf transferases.

Combinatorial approaches to iminosugars as glycosidase and glycosyltransferase inhibitors.

Hydrophilic iminosugar active-site-specific chaperones increase residual glucocerebrosidase activity in fibroblasts from Gaucher patients.

Synthesis of naturally occurring iminosugars from D-fructose by the use of a zinc-mediated fragmentation reaction.

Divergent synthesis of L-sugars and L-iminosugars from D-sugars.

Flexible synthesis and biological evaluation of novel 5-deoxyadenophorine analogues.