Latest papers

Orientation-dependent interaction between Drosophila insulators is a property of this class of regulatory elements.

[Several copies of insulator from MDG4 can determine the interaction between positively and negatively acting regulatory elements and promoter of the miniwhite gene of Drosophila melanogaster]

TFIIIC binding sites function as both heterochromatin barriers and chromatin insulators in Saccharomyces cerevisiae.

Chromatin insulators: regulatory mechanisms and epigenetic inheritance.

Insulation of the ubiquitous Rxrb promoter from the cartilage-specific adjacent gene, Col11a2.

Modulation of CTCF insulator function by transcription of a noncoding RNA.

Three-dimensional conformation at the H19/Igf2 locus supports a model of enhancer tracking.

Dysregulated human renin expression in transgenic mice carrying truncated genomic constructs: evidence supporting the presence of insulators at the renin locus.

The Ars insulator facilitates I-SceI meganuclease-mediated transgenesis in the sea urchin embryo.

[Function of cohesin in transcription]

Enhancer-promoter communication is regulated by insulator pairing in a Drosophila model bigenic locus.

Detection and characterization of silencers and enhancer-blockers in the greater CFTR locus.

Investigation of the properties of non-gypsy suppressor of hairy-wing-binding sites.

Chicken beta-globin insulator overcomes variegation of transgenes in Xenopus embryos.

CTCF physically links cohesin to chromatin.

Enhancer blocking activity of the insulator at H19-ICR is independent of chromatin barrier establishment.

'Insulator bodies' are aggregates of proteins but not of insulators.

Current status of globin gene therapy for the treatment of beta-thalassaemia.

An inducible and reversible mouse genetic rescue system.

Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes.