Latest papers

Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation.

[Cerebral proteolysis of amiloid-b peptide: relevance of insulin-degrading enzyme in Alzheimer's disease]

[Association of insulinase gene polymorphisms with type 2 diabetes mellitus in patients from the Moscow population]

Hypercholesterolemia-induced Abeta accumulation in rabbit brain is associated with alteration in IGF-1 signaling.

IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia.

Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues.

Stem cell antigen-1 localizes to lipid microdomains and associates with insulin degrading enzyme in skeletal myoblasts.

Differential scanning calorimetry study on drug release from an inulin-based hydrogel and its interaction with a biomembrane model: pH and loading effect.

Evidence that the gene encoding insulin degrading enzyme influences human lifespan.

Amyloid beta-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin.

Association of genetic variants of insulin degrading enzyme with metabolic features in women with polycystic ovary syndrome.

Molecular basis for the thiol sensitivity of insulin-degrading enzyme.

Increased expression of Abeta degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathology.

The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis.

Transglutaminase induces protofibril-like amyloid beta-protein assemblies that are protease-resistant and inhibit long-term potentiation.

Down-regulation of insulin-degrading enzyme by presenilin 1 V97L mutant potentially underlies increased levels of amyloid beta 42.

The irreversible binding of amyloid peptide substrates to insulin-degrading enzyme: a biological perspective.

Immunocapture-based fluorometric assay for the measurement of insulin-degrading enzyme activity in brain tissue homogenates.

[What is new in the genetics of type 2 diabetes]

Regional and cellular distribution patterns of insulin-degrading enzyme in the adult human brain and pituitary.