Latest papers

Alpha- and beta- aspartyl peptide ester formation via aspartimide ring opening.

Characterization of new D-beta-aspartate-containing proteins in a lens-derived cell line.

Biological significance of isoaspartate and its repair system.

Mechanism of the reaction catalyzed by isoaspartyl dipeptidase from Escherichia coli.

Hydroxytyrosol, a natural antioxidant from olive oil, prevents protein damage induced by long-wave ultraviolet radiation in melanoma cells.

Deamidation: Differentiation of aspartyl from isoaspartyl products in peptides by electron capture dissociation.

Mass spectrometric differentiation of alpha- and beta-aspartic acid in a pseudo-tetrapeptide thrombosis inhibitor and its isomer.

Solution structure and stability of the full-length excisionase from bacteriophage HK022.

A failure to repair self-proteins leads to T cell hyperproliferation and autoantibody production.

Suppression of Bcl-xL deamidation in human hepatocellular carcinomas.

Abeta species, including IsoAsp23 Abeta, in Iowa-type familial cerebral amyloid angiopathy.

Analysis of isoaspartate in a recombinant monoclonal antibody and its charge isoforms.

Down-regulation of protein L-isoaspartyl methyltransferase in human epileptic hippocampus contributes to generation of damaged tubulin.

The influence of protein structure on the products emerging from succinimide hydrolysis.

Development of a strong cation-exchange high-performance liquid chromatography method for analysis of isoaspartate in proteins.

The presence of D-beta-aspartic acid-containing peptides in elastic fibers of sun-damaged skin: a potent marker for ultraviolet-induced skin aging.

Folate status and age affect the accumulation of L-isoaspartyl residues in rat liver proteins.

Crystal structure of human L-isoaspartyl-O-methyl-transferase with S-adenosyl homocysteine at 1.6-A resolution and modeling of an isoaspartyl-containing peptide at the active site.

Detection of isoAspartate residues as a posttranslational modification of proteins and peptides.

Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate.