Latest papers

Isochore pattern and gene distribution in the chicken genome.

Isochore patterns and gene distributions in fish genomes.

Patterns of vertebrate isochore evolution revealed by comparison of expressed mammalian, avian, and crocodilian genes.

A markovian approach for the prediction of mouse isochores.

Discovering isochores by least-squares optimal segmentation.

Diversity in isochore structure among cold-blooded vertebrates based on GC content of coding and non-coding sequences.

Human chromosomal bands: nested structure, high-definition map and molecular basis.

Isochores and replication time zones: a perfect match.

The rate, not the spectrum, of base pair substitutions changes at a GC-content transition in the human NF1 gene region: implications for the evolution of the mammalian genome structure.

Are GC-rich isochores vanishing in mammals?

A new perspective on isochore evolution

A computational prediction of isochores based on hidden Markov models

Isochores exhibit evidence of genes interacting with the large-scale genomic environment.

GC-Profile: a web-based tool for visualizing and analyzing the variation of GC content in genomic sequences.

Significant positive correlation between the recombination rate and GC content in the human pseudoautosomal region.

Isochore structures in the chicken genome.

A novel method distinguishes between mutation rates and fixation biases in patterns of single-nucleotide substitution.

How not to search for isochores: a reply to Cohen et Al.

Meiosis-specific yeast Hop1 protein promotes pairing of double-stranded DNA helices via G/C isochores.

Relationships among stop codon usage bias, its context, isochores, and gene expression level in various eukaryotes.