Latest papers

Urinary C-peptide of insulin as a non-invasive marker of nutritional status: some practicalities.

Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery.

A single amino acid of human immunodeficiency virus type 2 capsid protein affects conformation of two external loops and viral sensitivity to TRIM5α.

Inhibition of sphingosine 1-phosphate lyase for the treatment of rheumatoid arthritis: discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime (LX2931) and (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932).

Lower respiratory tract infection in cynomolgus macaques (Macaca fascicularis) infected with group A Streptococcus

Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection.

Preexisting immunity and low expression in primates highlight translational challenges for liver-directed AAV8-mediated gene therapy.

Location of prorenin receptors in primate substantia nigra: effects on dopaminergic cell death.

[Computer modeling and simulation of bipedal walking in the Japanese macaque].

Non-human primate regulatory T cells: current biology and implications for transplantation.

Functional connectivity in the retina at the resolution of photoreceptors.

The complete genome and genetic characteristics of SRV-4 isolated from cynomolgus monkeys (Macaca fascicularis).

Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells.

Development in the cynomolgus macaque following administration of ustekinumab, a human anti-IL-12/23p40 monoclonal antibody, during pregnancy and lactation.

Primate testing of TGN1412: right target, wrong cell.

Primate models for cardiovascular drug research and development.

Vernakalant, a mixed sodium and potassium ion channel antagonist that blocks K(v)1.5 channels, for the potential treatment of atrial fibrillation.

Preclinical pharmacokinetics and in vitro metabolism of BMS-690514, a potent inhibitor of EGFR and VEGFR2.

Replacement of the condyle and ascending ramus by a modular endoprosthesis in Macaca fascicularis--part 3: evaluation of peri-implant bone remodeling.

Clonidine improves attentional and memory components of delayed response performance in a model of early Parkinsonism