Latest papers

Tandem aziridination/rearrangement reaction of allylic alcohols: an efficient approach to 2-quaternary Mannich bases.

Synthesis and anti-inflammatory activity of chalcones and related Mannich bases.

A formal enantioselective acetate Mannich reaction: the nitro functional group as a traceless agent for activation and enantiocontrol in the synthesis of beta-amino acids.

[Synthesis and antibacterial activity of imidazothiadiazoles and heterocyclic-amine Mannich-base hydrochloride].

Mechanistic studies on the catalytic asymmetric Mannich-type reaction with dihydroisoquinolines and development of oxidative Mannich-type reactions starting from tetrahydroisoquinolines.

Design, synthesis, and biological evaluation of Mannich bases of heterocyclic chalcone analogs as cytotoxic agents.

Asymmetric autocatalytic Mannich reaction in the presence of water and its implication in prebiotic chemistry.

Synthesis and pharmacological evaluation of 1-(1-((substituted)methyl)-5-methyl-2-oxoindolin-3-ylidene)-4-(substituted pyridin-2-yl)thiosemicarbazide.

Direct catalytic asymmetric Mannich-type reactions of gamma-butenolides: effectiveness of Brønsted acid in chiral metal catalysis.

A convenient route to enantiopure 3-aryl-2,3-diaminopropanoic acids by diastereoselective Mannich reaction of camphor-based tricyclic iminolactone with imines.

Spectroscopic properties of a strongly anharmonic Mannich base N-oxide.

Proline-catalysed Mannich reactions of acetaldehyde.

A new Heck reaction modification using ketone Mannich bases as enone precursors: parallel synthesis of anti-leishmanial chalcones.

Activity of Mannich bases of 7-hydroxycoumarin against Flaviviridae.

Cobalt-catalyzed reductive Mannich reactions of 4-acryloylmorpholine with N-tosyl aldimines.

Synthesis and evaluation of antiinflammatory and analgesic activities of a novel series of coumarin Mannich bases.

Development of an intravenous formulation of SU010382 (prodrug of SU5416, an anti-angiogenesis agent).

Effect of some bis Mannich bases and corresponding piperidinols on DNA topoisomerase I.

Attachment of peptide building blocks to proteins through tyrosine bioconjugation.

Synthesis of Schiff and Mannich bases of isatin derivatives with 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones.