Latest papers

Potentiated cytotoxic effects of statins and ajoene in murine melanoma cells.

Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells.

Simvastatin treatment induces morphology alterations and apoptosis in murine cochlear neuronal cells.

Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation.

Fluvastatin inhibits mast cell degranulation without changing the cytoplasmic Ca2+ level

Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay.

Inhibition of the mevalonate pathway potentiates the effects of lenalidomide in myeloma

Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway.

Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure.

Chinese red yeast rice versus lovastatin effects on prostate cancer cells with and without androgen receptor overexpression.

Modulation of osteoclastogenesis by fatty acids.

Analysis of the isoprenoid biosynthesis pathways in Listeria monocytogenes reveals a role for the alternative 2-C-methyl-D-erythritol 4-phosphate pathway in murine infection.

Peroxisomal localization of Arabidopsis isopentenyl diphosphate isomerases suggests that part of the plant isoprenoid mevalonic acid pathway is compartmentalized to peroxisomes.

Simvastatin inhibits catecholamine secretion and synthesis induced by acetylcholine via blocking Na+ and Ca2+ influx in bovine adrenal medullary cells.

Simvastatin-induced endothelial cell detachment and microparticle release are prenylation dependent.

Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation.

Cloning and characterization of mevalonate pathway genes in a natural rubber producing plant, Hevea brasiliensis.

Dysregulation of the host mevalonate pathway during early bacterial infection activates human TCR gamma delta cells.

Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants.

Statins and prostate cancer prevention: where we are now, and future directions.