Latest papers

Synthesis and characterization of a Hyaluronan-polyethylene copolymer for biomedical applications.

Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase.

Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01.

Advances in the diagnosis, pathogenesis, and management of autoimmune hepatitis.

Solid-phase synthetic route to multiple derivatives of a fundamental peptide unit.

Polysaccharide mimicry of the epitope of the broadly neutralizing anti-HIV antibody, 2G12, induces enhanced antibody responses to self oligomannose glycans.

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency.

Limitations of peptide retro-inverso isomerization in molecular mimicry.

Biased gene transfer mimics patterns created through shared ancestry.

[Peptidomimetic-based medicinal chemistry]

Receptor-mimic probiotics: potential therapeutics for bacterial toxin-mediated enteric diseases.

Inhibition of hepatitis C virus replication by single-stranded RNA structural mimics.

Remodeling of dynamic structures of HIV-1 envelope proteins leads to synthetic antigen molecules inducing neutralizing antibodies.

The lesion-mimic mutant cpr22 shows alterations in abscisic acid signaling and abscisic acid insensitivity in a salicylic acid-dependent manner.

Novel cyclic-imide peptidomimetics as aminopeptidase N inhibitors. Structure-based design, chemistry and activity evaluation. II.

Role of the guanidine group in the N-terminal fragment of PTH(1-11).

Design, synthesis and biological evaluation of non-peptide PAR1 thrombin receptor antagonists based on small bifunctional templates: arginine and phenylalanine side chain groups are keys for receptor activity.

Analogues of both Leu- and Met-enkephalin containing a constrained dipeptide isostere prepared from a Baylis-Hillman adduct.

Biomimetic synthesis and structural refinement of the macrocyclic dimer aminoglycoside 66-40C--the remarkably selective self-condensation of a putative aldehyde intermediate in the submerged culture medium producing sisomicin.

Synthesis of fluorinated C-mannopeptides as sialyl Lewisx mimics for E- and P-selectin inhibition.