Latest papers

The effect of cimetidine on dextromethorphan O-demethylase activity of human liver microsomes and recombinant CYP2D6.

Phenyl methyl ethers: novel electron donors for respiratory growth of Desulfitobacterium hafniense and Desulfitobacterium sp. strain PCE-S.

Signal quenching, detoxification and mineralization of vir gene-inducing phenolics by the VirH2 protein of Agrobacterium tumefaciens.

Stable expression of human cytochrome P450 2D6*10 in HepG2 cells.

Demethylation of radiolabelled dextromethorphan in rat microsomes and intact hepatocytes.

Identification of CYP1A2 as the main isoform for the phase I hydroxylated metabolism of genistein and a prodrug converting enzyme of methylated isoflavones.

Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase.

O-demethylation and sulfation of 7-methoxylated flavanones by Cunninghamella elegans.

Identification of new pisatin demethylase genes (PDA5 and PDA7) in Nectria haematococca and non-Mendelian segregation of pisatin demethylating ability and virulence on pea due to loss of chromosomal elements.

Characterization of mixtures of recombinant human cytochrome p450s as a screening model for metabolic stability in drug discovery.

Pisatin demethylase genes are on dispensable chromosomes while genes for pathogenicity on carrot and ripe tomato are on other chromosomes in Nectria haematococca.

CYP2D6.10 present in human liver microsomes shows low catalytic activity and thermal stability.

DNA methyltransferase and demethylase in human prostate cancer.

[Stress produced by contaminated sediments with nickel in a pond with rainbow trout Oncorhynchus mykiss (Pisces: Salmonidae)]

Host recognition by pathogenic fungi through plant flavonoids.

Extracting DNA demethylase activity from mammalian cells.

Measuring DNA demethylase activity in vitro.

Characterization of dextromethorphan O- and N-demethylation catalyzed by highly purified recombinant human CYP2D6.

DNA demethylase is expressed in ovarian cancers and the expression correlates with demethylation of CpG sites in the promoter region of c-erbB-2 and survivin genes.

The potential for CYP2D6 inhibition screening using a novel scintillation proximity assay-based approach.