Latest papers

Percutaneous penetration and distribution of VX using in vitro pig or human excised skin validation of demeton-S-methyl as adequate simulant for VX skin permeation investigations.

Association of paraoxonase activity and coronary blood flow.

Determination of active enzyme concentration using activity-based probes and direct mass spectrometric readout.

Inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds: pig versus minipig acetylcholinesterase.

Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase.

Synaptosomal GABA uptake decreases in paraoxon-treated rat brain.

Lipotoxic effects of triacylglycerols in J774.2 macrophages.

Alkali metal ion catalysis and inhibition in nucleophilic displacement reactions at phosphorus centers: ethyl and methyl paraoxon and ethyl and methyl parathion.

The organophosphate paraoxon has no demonstrable effect on the murine immune system following subchronic low dose exposure.

The organophosphate-induced acute-phase response is characterized by synthesis of alpha 1-acid glycoprotein that exhibits an immunomodulatory effect.

Nanoparticle-based electrochemical immunosensor for the detection of phosphorylated acetylcholinesterase: an exposure biomarker of organophosphate pesticides and nerve agents.

New oxime reactivators connected with CH2O(CH2)nOCH2 linker and their reactivation potency for organophosphorus agents-inhibited acetylcholinesterase.

Paraoxon inhibits GABA uptake in brain synaptosomes.

Photonic crystal sensor for organophosphate nerve agents utilizing the organophosphorus hydrolase enzyme.

Molecular cloning and expression of the C-terminal domain of mouse NTE-related esterase.

The reaction mechanism of paraoxon hydrolysis by phosphotriesterase from combined QM/MM simulations.

Impact of receptor changes on treatment of status epilepticus

Electrophysiological recording of re-aggregating brain cell cultures on multi-electrode arrays to detect acute neurotoxic effects.

Specificity of procaine and ester hydrolysis by human, minipig, and rat skin and liver.

Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase.