Latest papers

Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferase.

Cytochrome P4503A: evidence for mRNA expression and catalytic activity in rat brain.

Role for enhanced faecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity.

Expression and regulation of breast cancer resistance protein and multidrug resistance associated protein 2 in BALB/c mice.

Generation of specific antibodies and their use to characterize sex differences in four rat P450 3A enzymes following vehicle and pregnenolone 16alpha-carbonitrile treatment.

Microarray analysis on Phase II drug metabolizing enzymes expression in pregnant rats after treatment with pregnenolone-16alpha-carbonitrile or phenobarbital.

Potential role for human cytochrome P450 3A4 in estradiol homeostasis.

Clofibrate and perfluorodecanoate both upregulate the expression of the pregnane X receptor but oppositely affect its ligand-dependent induction on cytochrome P450 3A23.

Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms.

Histomorphological changes and cytochrome P450 isoforms expression and activities in precision-cut liver slices from neonatal rats.

Simultaneous substitution of phenylalanine-305 and aspartate-318 of rat pregnane X receptor with the corresponding human residues abolishes the ability to transactivate the CYP3A23 promoter.

Microarray analysis on CYPs expression in pregnant rats after treatment with pregnenolone-16alpha-carbonitrile and phenobarbital.

The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice.

Expression of PXR, CYP3A and MDR1 genes in liver of zebrafish.

Enhanced acetaminophen toxicity by activation of the pregnane X receptor.

Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver.

Suppression of DHEA sulfotransferase (Sult2A1) during the acute-phase response.

Promotion of thyroid tumors in rats by pregnenolone-16alpha-carbonitrile (PCN) and polychlorinated biphenyl (PCB).

Effect of prototypical inducing agents on P-glycoprotein and CYP3A expression in mouse tissues.

A transgenic mouse model with a luciferase reporter for studying in vivo transcriptional regulation of the human CYP3A4 gene.