Latest papers

Osteoprotegerin inhibits cartilage degradation through an effect on trabecular bone in murine experimental osteoarthritis.

Characterization of metalloprotease cleavage products of human articular cartilage.

GDNF hyperalgesia is mediated by PLCgamma, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican.

The regulation of aggrecanase ADAMTS-4 expression in human Achilles tendon and tendon-derived cells.

Molecular dissection of TIMP3 mutation S156C associated with Sorsby fundus dystrophy.

Evidence of a novel aggrecan-degrading activity in cartilage: Studies of mice deficient in both ADAMTS-4 and ADAMTS-5.

Natural chondroitin sulphates increase aggregation of proteoglycan complexes and decrease ADAMTS-5 expression in interleukin 1 beta-treated chondrocytes.

Multimodal signaling by the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) promotes neurite extension.

Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity.

Upregulation of tissue inhibitor of metalloproteases-1 (TIMP-1) and procollagen-N-peptidase in hypertension-induced renal damage.

Spingosine-1-phosphate stimulates proliferation and counteracts interleukin-1 induced nitric oxide formation in articular chondrocytes.

The occurrence of dermatosparaxis in a commercial Drakensberger cattle herd in South Africa.

Interleukin-4 antagonizes oncostatin M and transforming growth factor beta-induced responses in articular chondrocytes.

Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate.

ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques.

The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates.

Specific inhibition of procollagen C-endopeptidase activity by synthetic peptide with conservative sequence found in chordin.

Discordant localization of WFA reactivity and brevican/ADAMTS-derived fragment in rodent brain.

Aggrecanase and aggrecan degradation in osteoarthritis: a review.

The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review.