Latest papers

PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.

Inhibition of dengue virus by an ester prodrug of an adenosine analog.

Amphiphilic curcumin conjugate-forming nanoparticles as anticancer prodrug and drug carriers: in vitro and in vivo effects.

Synthesis and anti-HIV evaluation of new acyclic phosphonate nucleotide analogues and their bis(SATE) derivatives.

Tumor-specific gene transfer with receptor-mediated nanocomplexes modified by polyethylene glycol shielding and endosomally cleavable lipid and peptide linkers.

Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice.

Arbaclofen placarbil decreases postprandial reflux in patients with gastroesophageal reflux disease.

Improved plasma stability and sustained release profile of gemcitabine via polypeptide conjugation

Design, synthesis and evaluation of mutual prodrug of 4-biphenylacetic acid and quercetin tetramethyl ether (BPA-QTME) as gastrosparing NSAID.

Squalenoyl nucleoside monophosphate nanoassemblies: new prodrug strategy for the delivery of nucleotide analogues.

A prodrug approach towards the development of tricyclic-based FBPase inhibitors.

N(3)-o-toluyl-fluorouracil inhibits human hepatocellular carcinoma cell growth via sustained release of 5-FU.

Synthesis and characterization of a fluorescent water-soluble paclitaxel prodrug.

Peripheral site acetylcholinesterase inhibitors targeting both inflammation and cholinergic dysfunction.

Lisdexamfetamine dimesylate: a prodrug stimulant for the treatment of ADHD in children and adults.

In brief: poor metabolizers of clopidogrel (plavix).

Synthesis of the first spacer containing prodrug of a duocarmycin analogue and determination of its biological activity.

Self-assembly behavior of colistin and its prodrug colistin methanesulfonate: implications for solution stability and solubilization.

Simultaneous bioanalysis of a phosphate prodrug and its parent compound using a multiplexed LC-MS method.

Study of a cyclopamine glucuronide prodrug for the selective chemotherapy of glioblastoma