Latest papers

Proteome profiling suggests a pro-inflammatory role for plasma cells through release of high-mobility group box 1 protein.

Proteasome degradation of brain cytosolic tau in Alzheimer's disease.

Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials.

Changes in the leaf proteome profile of Mentha arvensis in response to Alternaria alternata infection.

ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycle.

CK1ε targets Cdc25A for ubiquitin-mediated proteolysis under normal conditions and in response to checkpoint activation.

[Systemic and molecular-genetic mechanisms of cardioprotection].

The tissue-specific Rep8/UBXD6 tethers p97 to the endoplasmic reticulum membrane for degradation of misfolded proteins.

C-terminal UBA domains protect ubiquitin receptors by preventing initiation of protein degradation.

Myoferlin gene silencing decreases Tie-2 expression in vitro and angiogenesis in vivo.

Adriamycin enhances proteasome-mediated generation of the proapoptotic processed form of MAGE-A4 in hepatoma cells.

Protective immunity remains intact after antibody removal by means of proteasome inhibition.

Hepatitis B virus induces expression of antioxidant response element-regulated genes by activation of Nrf2.

Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner.

Inhibition of all-trans-retinoic acid-induced proteasome activation potentiates the differentiating effect of retinoid in acute myeloid leukemia cells.

MDM2 promotes the proteasomal degradation of p73 through the interaction with Itch in HeLa cells

Kaposi's sarcoma-associated herpesvirus-encoded LANA positively affects on ubiquitylation of p53.

Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases.

Conformation states of the neuronal porosome complex.

Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis.