Latest papers

Targeting a Uniquely Nonspecific Prenyl Synthase with Bisphosphonates to Combat Cryptosporidiosis

Secondary structure of lipidated Ras bound to a lipid bilayer.

Protein farnesyltransferase-catalyzed isoprenoid transfer to peptide depends on lipid size and shape, not hydrophobicity.

Structure of protein geranylgeranyltransferase-I from the human pathogen Candida albicans complexed with a lipid substrate.

Ectopic expression of prelamin A in early Xenopus embryos induces apoptosis.

Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase by prenylation and interaction with a prenyl-binding protein.

Caged protein prenyltransferase substrates: tools for understanding protein prenylation.

A novel role for protein farnesylation in plant innate immunity.

The farnesylated nuclear proteins KUGELKERN and LAMIN B promote aging-like phenotypes in Drosophila flies.

Statins activate a mitochondria-operated pathway of apoptosis in breast tumor cells by a mechanism regulated by ErbB2 and dependent on the prenylation of proteins.

A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells.

High-content assay to study protein prenylation.

Effects of pharmacologic inhibition of protein geranylgeranyltransferase type I on aqueous humor outflow through the trabecular meshwork.

Computational prediction of the binding site of proteinase 3 to the plasma membrane.

Chemical site-selective prenylation of proteins.

Efficacy of a nitrogen-containing bisphosphonate, minodronate, in conjunction with a p38 mitogen activated protein kinase inhibitor or doxorubicin against malignant bone tumor cells.

Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division.

Effects of atorvastatin and pravastatin on signal transduction related to glucose uptake in 3T3L1 adipocytes.

Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells

Farnesylation of the SNARE protein Ykt6 increases its stability and helical folding.