Latest papers

Screening of LRRK2 interactants by yeast 2-hybrid analysis.

Modulation of functional properties of laforin phosphatase by alternative splicing reveals a novel mechanism for the EPM2A gene in Lafora progressive myoclonus epilepsy.

An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells.

Gene symbol: MTM1. Disease: Myotubular myopathy.

Characterization and functional studies of a FYVE domain-containing phosphatase in C. elegans.

PTP-Pez: a novel regulator of TGFbeta signaling.

AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.

Membrane traffic and muscle: lessons from human disease.

Lafora disease in the Indian population: EPM2A and NHLRC1 gene mutations and their impact on subcellular localization of laforin and malin.

Gene symbol: MTM1. Disease: Myotubular myopathy?

Gene symbol: MTM1. Disease: Myotubular myopathy.

Laforin confers cancer resistance to energy deprivation-induced apoptosis.

Gene symbol: MTM1. Disease: Myotubular myopathy.

A transgenic Drosophila model demonstrates that the Helicobacter pylori CagA protein functions as a eukaryotic Gab adaptor.

The Bro1-related protein HD-PTP/PTPN23 is required for endosomal cargo sorting and multivesicular body morphogenesis.

Expression and function of striatal enriched protein tyrosine phosphatase is profoundly altered in cerebral ischemia.

Protein-tyrosine phosphatase PTPD1 regulates focal adhesion kinase autophosphorylation and cell migration.

Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation.

Loss of the inactive myotubularin-related phosphatase Mtmr13 leads to a Charcot-Marie-Tooth 4B2-like peripheral neuropathy in mice.

The N terminus controls sterol binding while the C terminus regulates the scaffolding function of OSBP.