Latest papers

Analysis of vasodilator responses to peroxynitrite in the hindlimb vascular bed of the cat.

Nonpolar isosteres of damaged DNA bases: effective mimicry of mutagenic properties of 8-oxopurines.

Celecoxib dilates guinea-pig coronaries and rat aortic rings and amplifies NO/cGMP signaling by PDE5 inhibition.

Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP.

Molecular modeling studies of pyridopurinone derivatives--potential phosphodiesterase 5 inhibitors.

Dual regulation of the ATP-sensitive potassium channel by caffeine.

Synthesis, biological testing, and binding mode prediction of 6,9-diarylpurin-8-ones as p38 MAP kinase inhibitors.

Low-Dose Phosphodiesterase Inhibition Improves Responsiveness to Inhaled Nitric Oxide in Isolated Lungs From Endotoxemic Rats

Bromophenols coupled with nucleoside bases and brominated tetrahydroisoquinolines from the red alga Rhodomela confervoides.

Negative functional effects of natriuretic peptides are attenuated in hypertrophic cardiac myocytes by reduced particulate guanylyl cyclase activity.

Comparative in vitro and in vivo studies on long-wavelength photosensitizers derived from bacteriopurpurinimide and Bacteriochlorin p6: fused imide ring enhances the in vivo PDT efficacy.

Hormonal regulation of the contractile vacuole in Amoeba proteus: the role of cyclic nucleotide phosphodiesterases.

Effects of phosphodiesterase (PDE) inhibitors on human ether-a-go-go related gene (hERG) channel activity.

Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35.

Monolithic silica columns with mixed mode of hydrophilic interaction and weak anion-exchange stationary phase for pressurized capillary electrochromatography.

Multiple metal binding to 6-oxopurine nucleobases as a source of deprotonation. The role of metal ions at N7 and N3.

The determinants of sensitivity and acquired resistance to gemcitabine differ in non-small cell lung cancer: a role of ABCC5 in gemcitabine sensitivity.

cGMP stimulates renin secretion in vivo by inhibiting phosphodiesterase-3.

Nitric oxide and prostaglandins potentiate the liver regeneration cascade.

Zaprinast consolidates long-term memory when administered to neonate chicks trained using a weakly reinforced single trial passive avoidance task.