Latest papers

Inhibition of activation of dsRNA-dependent protein kinase and tumour growth inhibition.

Mechanism of inhibition of ribonucleotide reductase with motexafin gadolinium (MGd).

Unchanged thymidine triphosphate pools and thymidine metabolism in two lines of thymidine kinase 2-mutated fibroblasts.

Mouse models of mitochondrial DNA defects and their relevance for human disease.

Pancreatic cancer: translating lessons from mouse models.

GTI-2040 displays cooperative anti-tumor activity when combined with interferon alpha against human renal carcinoma xenografts.

Impact of adjuvant gemcitabine plus S-1 chemotherapy after surgical resection for adenocarcinoma of the body or tail of the pancreas.

Clinical pharmacology and pharmacogenetics of gemcitabine.

Formation and function of the Manganese(IV)/Iron(III) cofactor in Chlamydia trachomatis ribonucleotide reductase.

The intrinsically disordered RNR inhibitor Sml1 is a dynamic dimer.

Mouse models of oxidative phosphorylation dysfunction and disease.

Synthesis and ribonucleotide reductase inhibitory activity of thiosemicarbazones.

Electron transfer in peptides and proteins

Dif1 controls subcellular localization of ribonucleotide reductase by mediating nuclear import of the R2 subunit.

ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage.

Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage.

Mapping the subunit interface of ribonucleotide reductase (RNR) using photo cross-linking.

Structural analysis of the Mn(IV)/Fe(III) cofactor of Chlamydia trachomatis ribonucleotide reductase by extended X-ray absorption fine structure spectroscopy and density functional theory calculations.

p53-inducible ribonucleotide reductase (p53R2/RRM2B) is a DNA hypomethylation-independent decitabine gene target that correlates with clinical response in myelodysplastic syndrome/acute myelogenous leukemia.

Circular dichroism and magnetic circular dichroism studies of the biferrous site of the class Ib ribonucleotide reductase from Bacillus cereus: comparison to the class Ia enzymes.