Latest papers

Inhibition of S6K by resveratrol: in search of the purpose.

Components of the mitogen-activated protein kinase cascade are activated in hepatic cells by Echinococcus multilocularis metacestode.

Synergistic effect of Sorafenib and Sunitinib with Enzastaurin, a selective protein kinase C inhibitor in renal cell carcinoma cell lines

Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway

Not all substrates are treated equally: implications for mTOR, rapamycin-resistance and cancer therapy.

mTORC1 signalling and mRNA translation.

Nutrient-dependent regulation of autophagy through the target of rapamycin pathway.

Regulation and localization of ribosomal protein S6 kinase 1 isoforms.

Stress and signaling responses of rat skeletal muscle to brief endurance exercise during hindlimb unloading: a catch-up process for atrophied muscle.

CXCR6 induces prostate cancer progression by the AKT/mammalian target of rapamycin signaling pathway.

RalA functions as an indispensable signal mediator for the nutrient-sensing system.

CD40-induced signaling in human endothelial cells results in mTORC2- and Akt-dependent expression of vascular endothelial growth factor in vitro and in vivo.

Fatty acid synthase inhibitors modulate energy balance via mammalian target of rapamycin complex 1 signaling in the central nervous system.

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation.

Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formation.

mTOR mediates survival signals in malignant mesothelioma grown as tumor fragment spheroids.

A PI3-kinase-mediated negative feedback regulates neuronal excitability.

Negative effects of the amino acids Lys, His, and Thr on S6K1 phosphorylation in mammary epithelial cells.

Serine 396 of PDK1 is required for maximal PKB activation

Shp2 negatively regulates growth in cardiomyocytes by controlling focal adhesion kinase/Src and mTOR pathways.