Latest papers

An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival.

Reduction of Shp-2 expression by small interfering RNA reduces murine embryonic stem cell-derived in vitro hematopoietic differentiation.

Pinpointing phosphotyrosine-dependent interactions downstream of the collagen receptor DDR1.

[Clinical symptoms and molecular pathogenesis of Noonan syndrome--current concepts].

Ligation of CD28 stimulates the formation of a multimeric signaling complex involving grb-2-associated binder 2 (gab2), SRC homology phosphatase-2, and phosphatidylinositol 3-kinase: evidence that negative regulation of CD28 signaling requires the gab2 pleckstrin homology domain.

Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains.

A SHPing tale: perspectives on the regulation of SHP-1 and SHP-2 tyrosine phosphatases by the C-terminal tail.

[Regulation of the immune system by protein tyrosine phosphatases]

Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes.

Little response to zoledronic acid in a child of juvenile myelomonocytic leukemia (JMML) harboring the PTPN11 mutation.

Active Ca2+/calmodulin-dependent protein kinase II gamma B impairs positive selection of T cells by modulating TCR signaling.

Receptor-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-76-ADAP.

Characterization of inhibitory signaling motifs of the natural killer cell receptor Siglec-7: attenuated recruitment of phosphatases by the receptor is attributed to two amino acids in the motifs.

Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244).

Genotypic and phenotypic characterization of Noonan syndrome: new data and review of the literature.

[Noonan syndrome and Leopard syndrome linked to mutation of the gene PTPN11].

Denervation enhances the expression of SHPS-1 in rat skeletal muscle.

The role of CD150-SH2D1A association in CD150 signaling in Hodgkin's lymphoma cell lines.

Host adaptor proteins Gab1 and CrkII promote InlB-dependent entry of Listeria monocytogenes.

Functional analysis of PTPN11/SHP-2 mutants identified in Noonan syndrome and childhood leukemia.